FOXO proteins are transcription factors that are involved in numerous physiological processes and in various pathological conditions, including cardiovascular disease, cancer, diabetes and chronic neurological diseases. For example, FOXO proteins are context-dependent tumour suppressors that are frequently inactivated in human cancers, and FOXO3 is the second most replicated gene associated with extreme human longevity. Therefore, pharmacological manipulation of FOXO proteins is a promising approach to developing therapeutics for cancer and for healthy ageing. In this Review, we overview the role of FOXO proteins in health and disease and discuss the pharmacological approaches to modulate FOXO function.

FOXO蛋白是转录因子，涉及许多生理过程和各种病理状况，包括心血管疾病，癌症，糖尿病和慢性神经系统疾病。例如，FOXO蛋白是上下文相关的肿瘤抑制因子，在人类癌症中经常失活，而FOXO3是与人类极度长寿相关的第二大复制基因。因此，FOXO蛋白的药理学操纵是开发用于癌症和健康衰老的疗法的有前途的方法。在这篇综述中，我们概述了FOXO蛋白在健康和疾病中的作用，并讨论了调节FOXO功能的药理方法。