Ovarian cancer (OC) is one of the most prevalent and deadly types of gynecological malignancy. Since current treatments are not effective against OC, it is imperative to develop novel potential therapeutic targets for managing OC. In this study, we aimed to uncover the underlying molecular mechanism of long non-coding RNA (lncRNA) GClnc1 related to p53 signaling pathway in OC. The expression of lncRNA H19 GClnc1 was markedly higher in OC samples than the related normal tissues. Next, we found that lncRNA GClnc1 inhibited p53. In addition, the lncRNA GClnc1 overexpression promoted the cell proliferation and migration in vitro. Subsequently, p53 silencing obligated the effect of lncRNA GCln1 knock down on cell proliferation and migration. To sum up, LncRNA GClnc1 contributes to the progression of OC by regulating p53 signaling pathway. Meanwhile, our findings also suggested that lncRNA GClnc1 may serve as a novel therapeutic target for OC patients.

卵巢癌（OC）是妇科恶性肿瘤中最普遍和致命的类型之一。由于目前的疗法对OC无效，因此必须开发出新的潜在治疗靶点来管理OC。在这项研究中，我们旨在揭示与OC中p53信号通路相关的长非编码RNA（lncRNA）GClnc1的潜在分子机制。OC样品中lncRNA H19 GClnc1的表达明显高于相关正常组织。接下来，我们发现lncRNA GClnc1抑制了p53。另外，lncRNA GClnc1的过表达促进了细胞的增殖和迁移。。随后，p53沉默迫使lncRNA GCln1敲低对细胞增殖和迁移的影响。综上所述，LncRNA GClnc1通过调节p53信号通路来促进OC的发展。同时，我们的发现还表明，lncRNA GClnc1可以作为OC患者的新型治疗靶点。