Diabetes is marked by a range of complications, including chronic infections that can lead to limb amputation. The treatment of infected wounds is disrupted by arteriopathies that reduce tissue perfusion as well as by the critical development of bacterial resistance. We evaluated the impact of a local application of bacteriophages compared to that of a per os administration of amoxicillin-clavulanic acid in a mouse model of Staphylococcus aureus wound infection. We found that phage treatment resulted in improved clinical healing and a reduction in local bacterial load at 7 and 14 days postinfection. Unlike antibiotics, phage therapy did not deplete the intestinal microbiota of treated animals. Amoxicillin resulted in a reduction of alpha and beta diversities of the murine microbiota and disturbed architecture even 7 days after the end of treatment, whereas phage treatment did not impinge on the microbiota.

中文翻译：

---

噬菌体与抗生素在小鼠模型中治疗感染的糖尿病伤口：微生物学和微生物学评估

糖尿病的特征是一系列并发症，包括可能导致截肢的慢性感染。被感染的伤口的治疗被减少组织灌注的动脉病以及细菌耐药性的严重发展所中断。我们评估了噬菌体的本地应用程序相比，一个影响口服在小鼠模型中给予阿莫西林-克拉维酸的金黄色葡萄球菌伤口感染。我们发现噬菌体治疗可在感染后7天和14天改善临床愈合并减少局部细菌负荷。与抗生素不同，噬菌体疗法不会耗尽所治疗动物的肠道菌群。阿莫西林甚至在治疗结束后7天也导致鼠类微生物群的α和β多样性降低，并扰乱了结构，而噬菌体治疗并未影响微生物群。