Background: Longitudinal follow-up of older persons living with HIV is essential for the ascertainment of aging-related clinical and behavioral outcomes, and self-administered questionnaires are necessary for collecting behavioral information in research involving persons living with HIV. Web-based self-reported data collection results in higher data quality than paper-and-pencil questionnaires in a wide range of populations. The option of remote web-based surveys may also increase retention in long-term research studies. However, the acceptability and feasibility of web-based data collection in clinical research involving older persons living with HIV have never been studied. Objective: This study aims to assess the acceptability and feasibility of a web-based survey to collect information on sexual, substance use, and physical activity behaviors; compare the data quality of the web-based survey with that of a paper-and-pencil questionnaire; and summarize web-based survey metrics. Methods: This pilot study took place within the AIDS Clinical Trials Group A5322 study, a longitudinal cohort of men and women living with HIV (aged ≥40 years), followed at 32 clinical sites in the United States and Puerto Rico. A total of 4 sites participated in this study. A web-based survey was created using self-administered questionnaires typically completed in A5322 via paper and pencil. Pilot study participants completed these questionnaires via web-based survey at one research visit in lieu of paper-and-pencil administration. Two questions were added to assess feasibility, defined as participants’ perception of the ease of web-based survey completion (very hard, hard, easy, very easy), and their preferred format (computer or tablet, paper and pencil, no preference) for completing the questions in the future (acceptability). Feasibility and acceptability were summarized overall and by demographic and clinical characteristics; the proportion of evaluable data by web-based survey versus previously administered paper-and-pencil questionnaires (data quality) was compared for each question. Results: Acceptability and feasibility were high overall: 50.0% (79/158) preferred computer or tablet, 38.0% (60/158) reported no preference, and 12.0% (19/158) preferred paper and pencil; 93.0% (147/158) reported survey completion easy or very easy. Older age was associated with lower odds of preferring computer or tablet to paper and pencil (odds ratio per 1-year increase in age: 0.91, 95% CI 0.85-0.98). Individuals who found the survey hard or very hard had a lower median neurocognitive test score than those who found it easy or very easy. Data quality with web-based survey administration was similar to or higher than that with paper-and-pencil administration for most questions. Conclusions: Web-based survey administration was acceptable and feasible in this cohort of older adults living with HIV, and data quality was high. Web-based surveys can be a useful tool for valid data collection and can potentially improve retention in long-term follow-up studies.

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中文翻译：

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在临床研究环境中为感染 HIV 的老年人收集基于网络的数据：初步观察性研究

背景：对艾滋病毒感染者的纵向随访对于确定与衰老相关的临床和行为结果至关重要，并且在涉及艾滋病毒感染者的研究中收集行为信息需要自我管理的问卷调查。在广泛的人群中，基于网络的自我报告数据收集比纸笔问卷具有更高的数据质量。远程网络调查的选项也可能增加长期研究的保留率。然而，在涉及感染艾滋病毒的老年人的临床研究中，基于网络的数据收集的可接受性和可行性从未被研究过。目的：本研究旨在评估基于网络的调查的可接受性和可行性，以收集有关性、物质使用和身体活动行为的信息；将网络调查的数据质量与纸笔问卷的数据质量进行比较；并总结基于网络的调查指标。方法：这项试点研究在 AIDS 临床试验组 A5322 研究中进行，该研究是一个纵向队列，由感染 HIV 的男性和女性（年龄≥40 岁）组成，随后在美国和波多黎各的 32 个临床地点进行。共有 4 个站点参与了这项研究。使用通常通过纸和铅笔在 A5322 中完成的自我管理问卷创建了基于网络的调查。试点研究参与者在一次研究访问中通过基于网络的调查完成了这些问卷调查，以代替纸笔管理。添加了两个问题来评估可行性，定义为参与者对基于网络的调查完成难易程度的看法（非常难、难、容易、非常容易），以及他们未来完成问题的首选格式（计算机或平板电脑、纸和铅笔，无偏好）（可接受性）。根据人口统计学和临床​​特征对可行性和可接受性进行了总体总结；针对每个问题，比较了基于网络调查的可评估数据与以前使用的纸笔问卷（数据质量）的比例。结果：可接受性和可行性总体较高：50.0% (79/158) 首选计算机或平板电脑，38.0% (60/158) 报告无偏好，12.0% (19/158) 首选纸和铅笔；93.0% (147/158) 报告调查完成很容易或非常容易。与纸和铅笔相比，年龄越大更喜欢电脑或平板电脑的几率越低（年龄每增加 1 年的几率：0.91，95% CI 0.85-0.98）。发现调查困难或非常困难的人的神经认知测试分数中位数低于那些发现容易或非常容易的人。对于大多数问题，基于网络的调查管理的数据质量与纸笔管理的数据质量相似或更高。结论：基于网络的调查管理在这群感染 HIV 的老年人中是可以接受和可行的，并且数据质量很高。基于网络的调查可以成为有效数据收集的有用工具，并有可能提高长期随访研究的保留率。在这群感染艾滋病毒的老年人中，基于网络的调查管理是可以接受和可行的，并且数据质量很高。基于网络的调查可以成为有效数据收集的有用工具，并有可能提高长期随访研究的保留率。在这群感染艾滋病毒的老年人中，基于网络的调查管理是可以接受和可行的，并且数据质量很高。基于网络的调查可以成为有效数据收集的有用工具，并有可能提高长期随访研究的保留率。

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