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THE INFLUENCE OF TDCS INTENSITY ON DECISION-MAKING TRAINING AND TRANSFER OUTCOMES
Journal of Neurophysiology ( IF 2.1 ) Pub Date : 2020-11-11 , DOI: 10.1152/jn.00423.2020
Shane E Ehrhardt 1 , Hannah L Filmer 1 , Yohan Wards 1 , Jason B Mattingley 1, 2, 3 , Paul E Dux 1
Affiliation  

Transcranial direct current stimulation (tDCS) has been shown to improve single- and dual-task performance in healthy participants and enhance transferable training gains following multiple sessions of combined stimulation and task-practice. However, it has yet to be determined what the optimal stimulation dose is for facilitating such outcomes. We aimed to test the effects of different tDCS intensities, with a commonly used electrode montage, on performance outcomes in a multi-session single/dual-task training and transfer protocol. In a pre-registered study, 123 participants, who were pseudorandomised across four groups, each completed six sessions (pre- and post-training sessions and four combined tDCS and training sessions) and received 20 minutes of prefrontal anodal tDCS at 0.7 mA, 1.0 mA, 2.0 mA, or 15-second sham stimulation. Response time and accuracy were assessed in trained and untrained tasks. The 1.0 mA group showed substantial improvements in single-task reaction time and dual-task accuracy, with additional evidence for improvements in dual-task reaction times, relative to sham performance. This group also showed near transfer to the single-task component of an untrained multitasking paradigm. The 0.7 mA and 2.0 mA intensities varied in which performance measures they improved on the trained task, but in sum, the effects were less robust than for the 1.0 mA group and there was no evidence for the transfer of performance. Our study highlights that training performance gains are augmented by tDCS, but their magnitude and nature are not uniform across stimulation intensity.

中文翻译:

TDCS 强度对决策培训和转移结果的影响

经颅直流电刺激 (tDCS) 已被证明可以改善健康参与者的单任务和双任务表现,并在多次组合刺激和任务练习后提高可转移的训练收益。然而,尚未确定促进此类结果的最佳刺激剂量是多少。我们旨在通过常用的电极蒙太奇测试不同 tDCS 强度对多会话单/双任务训练和传输协议中的性能结果的影响。在一项预先注册的研究中,123 名参与者伪随机分为四组,每组完成六节课(训练前和训练后以及四节 tDCS 和训练相结合的课程),并在 0.7 mA、1.0 电流下接受 20 分钟的前额叶阳极 tDCS mA、2.0 mA 或 15 秒假刺激。在受过训练和未经训练的任务中评估了响应时间和准确性。1.0 mA 组在单任务反应时间和双任务准确性方面显示出显着改善,并有更多证据表明双任务反应时间相对于假性能有所改善。该组还表现出几乎转移到未经训练的多任务处理范式的单任务组件。0.7 mA 和 2.0 mA 强度不同,它们在训练任务中改善的性能测量,但总而言之,效果不如 1.0 mA 组强,并且没有性能转移的证据。我们的研究强调,tDCS 增强了训练性能的提高,但它们的幅度和性质在刺激强度上并不统一。0 mA 组显示出单任务反应时间和双任务准确性的显着改善,并有额外的证据表明双任务反应时间相对于假性能有所改善。该组还表现出几乎转移到未经训练的多任务处理范式的单任务组件。0.7 mA 和 2.0 mA 强度不同,它们在训练任务中改善的性能测量,但总而言之,效果不如 1.0 mA 组强,并且没有性能转移的证据。我们的研究强调,tDCS 增强了训练性能的提高,但它们的幅度和性质在刺激强度上并不统一。0 mA 组显示出单任务反应时间和双任务准确性的显着改善,并有额外的证据表明双任务反应时间相对于假性能有所改善。该组还表现出几乎转移到未经训练的多任务处理范式的单任务组件。0.7 mA 和 2.0 mA 强度不同,它们在训练任务中改善的性能测量,但总而言之,效果不如 1.0 mA 组强,并且没有性能转移的证据。我们的研究强调,tDCS 增强了训练性能的提高,但它们的幅度和性质在刺激强度上并不统一。该组还表现出几乎转移到未经训练的多任务处理范式的单任务组件。0.7 mA 和 2.0 mA 强度不同,它们在训练任务中改善的性能测量,但总而言之,效果不如 1.0 mA 组强,并且没有性能转移的证据。我们的研究强调,tDCS 增强了训练性能的提高,但它们的幅度和性质在刺激强度上并不统一。该组还表现出几乎转移到未经训练的多任务处理范式的单任务组件。0.7 mA 和 2.0 mA 强度不同,它们在训练任务中改善的性能测量,但总而言之,效果不如 1.0 mA 组强,并且没有性能转移的证据。我们的研究强调,tDCS 增强了训练性能的提高,但它们的幅度和性质在刺激强度上并不统一。
更新日期:2020-11-12
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