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Inhibition of interleukin‐1β signalling promotes atherosclerotic lesion remodelling in mice with inflammatory arthritis
Clinical & Translational Immunology ( IF 5.8 ) Pub Date : 2020-11-09 , DOI: 10.1002/cti2.1206 Dragana Dragoljevic 1, 2 , Man Kit Sam Lee 1, 2 , Cynthia Louis 3 , Waled Shihata 1 , Michael J Kraakman 1 , Jacinta Hansen 3 , Seth L Masters 3 , Beatriz Y Hanaoka 4 , Prabhakara R Nagareddy 4 , Graeme I Lancaster 1, 2 , Ian P Wicks 3, 5 , Andrew J Murphy 1, 2
Clinical & Translational Immunology ( IF 5.8 ) Pub Date : 2020-11-09 , DOI: 10.1002/cti2.1206 Dragana Dragoljevic 1, 2 , Man Kit Sam Lee 1, 2 , Cynthia Louis 3 , Waled Shihata 1 , Michael J Kraakman 1 , Jacinta Hansen 3 , Seth L Masters 3 , Beatriz Y Hanaoka 4 , Prabhakara R Nagareddy 4 , Graeme I Lancaster 1, 2 , Ian P Wicks 3, 5 , Andrew J Murphy 1, 2
Affiliation
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Rheumatoid arthritis (RA), an inflammatory joint disorder, independently increases the risk of cardiovascular disease (CVD). IL‐1β contributes to both RA and CVD. We hypothesised that inhibiting IL‐1 signalling with the IL‐1R antagonist, anakinra, would dampen inflammation and promote resolution of atherosclerosis in arthritic mice.
中文翻译：
抑制白细胞介素-1β信号传导促进炎症性关节炎小鼠的动脉粥样硬化病变重塑
类风湿性关节炎 (RA) 是一种炎症性关节疾病，会单独增加心血管疾病 (CVD) 的风险。IL-1β 会导致 RA 和 CVD。我们假设用 IL-1R 拮抗剂阿那白滞素抑制 IL-1 信号传导可以抑制关节炎小鼠的炎症并促进动脉粥样硬化的消退。
更新日期：2020-11-12
中文翻译：
抑制白细胞介素-1β信号传导促进炎症性关节炎小鼠的动脉粥样硬化病变重塑
类风湿性关节炎 (RA) 是一种炎症性关节疾病，会单独增加心血管疾病 (CVD) 的风险。IL-1β 会导致 RA 和 CVD。我们假设用 IL-1R 拮抗剂阿那白滞素抑制 IL-1 信号传导可以抑制关节炎小鼠的炎症并促进动脉粥样硬化的消退。
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