Exercise‐linked improvement in age‐associated loss of balance is associated with increased vestibular input to motor neurons,Aging Cell

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Exercise‐linked improvement in age‐associated loss of balance is associated with increased vestibular input to motor neurons
Aging Cell ( IF 8.0 ) Pub Date : 2020-11-11 , DOI: 10.1111/acel.13274
Fabienne Battilana ₁ , Stefan Steurer ₁ , Giorgio Rizzi ₁ , Ana C Delgado ₁ , Kelly R Tan ₁ , Christoph Handschin ₁

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Age‐associated loss of muscle function is exacerbated by a concomitant reduction in balance, leading to gait abnormalities and falls. Even though balance defects can be mitigated by exercise, the underlying neural mechanisms are unknown. We now have investigated components of the proprioceptive and vestibular systems in specific motor neuron pools in sedentary and trained old mice, respectively. We observed a strong age‐linked deterioration in both circuits, with a mitigating effect of exercise on vestibular synapse numbers on motor neurons, closely associated with an improvement in gait and balance in old mice. Our results thus describe how the proprioceptive and vestibular systems are modulated by age and exercise, and how these changes affect their input to motor neurons. These findings not only make a strong case for exercise‐based interventions in elderly individuals to improve balance, but could also lead to targeted therapeutic interventions aimed at the respective neuronal circuitry.

中文翻译：

与年龄相关的平衡丧失的运动相关改善与运动神经元的前庭输入增加有关

伴随着平衡的降低，会加剧与年龄相关的肌肉功能丧失，导致步态异常和跌倒。尽管运动可以减轻平衡缺陷，但潜在的神经机制尚不清楚。我们现在已经分别研究了久坐不动和训练有素的老小鼠中特定运动神经元池中本体感觉和前庭系统的组成部分。我们观察到两个回路都出现了与年龄相关的严重退化，运动对运动神经元上的前庭突触数量有缓解作用，这与老年小鼠步态和平衡的改善密切相关。因此，我们的结果描述了本体感觉和前庭系统如何受年龄和运动的调节，以及这些变化如何影响它们对运动神经元的输入。

更新日期：2020-12-17

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