Discovery of Natural Co‐occurring Enantiomers of Monoterpenoid Indole Alkaloids,Chinese Journal of Chemistry

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Discovery of Natural Co‐occurring Enantiomers of Monoterpenoid Indole Alkaloids
Chinese Journal of Chemistry ( IF 5.5 ) Pub Date : 2020-11-10 , DOI: 10.1002/cjoc.202000574
Yang Yu ₁ , Mei–Fen Bao ₁ , Xiang–Hai Cai ₁

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Two new pairs of monoterpenoid indole alkaloids (MIAs) enantiomers as well as their new congeners were isolated from stems of Tabernaemontana bovina Lour. (Apocynaceae). Their structures were elucidated by spectroscopic analyses and confirmed by X‐ray diffractions and computational calculations. Tabovine A, tabovine B and tabovines C—D possessed unprecedented 6/5/5/6/6, 6/5/5/6/5 and 6/5/6/6/6 ring systems, respectively. It is the first time to report co‐occurring enantiomers of MIAs. Additionally, the explanation concerning biogenesis of MIAs was provided. The findings would open a new window where we could disclose more diverse MIAs.

中文翻译：

发现单萜类吲哚生物碱的天然共生对映体

从Tabernaemontana bovina Lour的茎中分离出两对新的单萜类吲哚生物碱（MIA）对映体及其新同源物。（夹竹桃科）。通过光谱分析阐明了它们的结构，并通过X射线衍射和计算计算证实了它们的结构。Tabovine A，Tabovine B和Tabovines C-D分别拥有空前的6/5/5/6 / 6、6 / 5/5/6/5和6/5/6/6/6环系统。这是首次报道MIA的共存对映异构体。另外，提供了关于MIA的生物发生的解释。这些发现将打开一个新的窗口，在这里我们可以披露更多不同的MIA。

更新日期：2020-11-10

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