The unusual occurrence and developmental diversity of asexual eukaryotes remain a puzzle. De novo formation of a functioning asexual genome requires a unique assembly of sets of genes or gene states to disrupt cellular mechanisms of meiosis and gametogenesis, and to affect discrete components of sexuality and produce clonal or hemiclonal offspring. We highlight two usually overlooked but essential conditions to understand the molecular nature of clonal organisms, that is, a nonrecombinant genomic assemblage retaining modifiers of the sexual program, and a complementation between altered reproductive components. These subtle conditions are the basis for physiologically viable and genetically balanced transitions between generations. Genomic and developmental evidence from asexual animals and plants indicates the lack of complementation of molecular changes in the sexual reproductive program is likely the main cause of asexuals' rarity, and can provide an explanatory frame for the developmental diversity and lability of developmental patterns in some asexuals as well as for the discordant time to extinction estimations.

中文翻译：

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跳过性别：互补生殖模块的非重组基因组组合

无性真核生物的异常发生和发育多样性仍然是一个谜。功能性无性基因组的从头形成需要一组独特的基因组或基因状态，以破坏减数分裂和配子发生的细胞机制，并影响性的离散组成部分并产生克隆或半克隆后代。我们强调了两个通常被忽视但必不可少的条件，以了解克隆生物的分子性质，即保留性程序修饰符的非重组基因组组合，以及改变的生殖成分之间的互补。这些微妙的条件是代际间生理上可行和遗传平衡过渡的基础。