The changing chromatome as a driver of disease: A panoramic view from different methodologies,BioEssays

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The changing chromatome as a driver of disease: A panoramic view from different methodologies
BioEssays ( IF 3.2 ) Pub Date : 2020-11-09 , DOI: 10.1002/bies.202000203
Isabel Espejo ₁ , Luciano Di Croce _{1,

2,

3} , Sergi Aranda ₁

Affiliation

Chromatin‐bound proteins underlie several fundamental cellular functions, such as control of gene expression and the faithful transmission of genetic and epigenetic information. Components of the chromatin proteome (the “chromatome”) are essential in human life, and mutations in chromatin‐bound proteins are frequently drivers of human diseases, such as cancer. Proteomic characterization of chromatin and de novo identification of chromatin interactors could, thus, reveal important and perhaps unexpected players implicated in human physiology and disease. Recently, intensive research efforts have focused on developing strategies to characterize the chromatome composition. In this review, we provide an overview of the dynamic composition of the chromatome, highlight the importance of its alterations as a driving force in human disease (and particularly in cancer), and discuss the different approaches to systematically characterize the chromatin‐bound proteome in a global manner.

中文翻译：

不断变化的染色体驱动疾病：不同方法的全景图

染色质结合蛋白是几种基本的细胞功能的基础，例如基因表达的控制以及遗传和表观遗传信息的忠实传递。染色质蛋白质组的组成部分（“染色质”）是人类生活中必不可少的，染色质结合蛋白中的突变通常是人类疾病（例如癌症）的驱动因素。染色质和从头蛋白质组学表征因此，染色质相互作用子的鉴定可以揭示与人类生理学和疾病有关的重要且可能是出乎意料的参与者。近来，大量的研究工作集中在开发表征色谱原子组成的策略上。在这篇综述中，我们概述了染色质的动态组成，强调了其变化作为人类疾病（尤其是癌症）的驱动力的重要性，并讨论了系统表征染色质结合的蛋白质组的不同方法。全球性的方式。

更新日期：2020-11-25

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