Age‐related changes in chimpanzee (Pan troglodytes) cognition: Cross‐sectional and longitudinal analyses,American Journal of Primatology

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Age‐related changes in chimpanzee (Pan troglodytes) cognition: Cross‐sectional and longitudinal analyses
American Journal of Primatology ( IF 2.0 ) Pub Date : 2020-11-10 , DOI: 10.1002/ajp.23214
William D Hopkins ₁ , Mary C Mareno ₁ , Sarah J Neal Webb ₁ , Steven J Schapiro _{1,

2} , Mary A Raghanti ₃ , Chet C Sherwood ₄

Affiliation

Chimpanzees are the species most closely related to humans, yet age‐related changes in brain and cognition remain poorly understood. The lack of studies on age‐related changes in cognition in chimpanzees is particularly unfortunate in light of the recent evidence demonstrating that this species naturally develops Alzheimer's disease (AD) neuropathology. Here, we tested 213 young, middle‐aged, and elderly captive chimpanzees on the primate cognitive test battery (PCTB), a set of 13 tasks that assess physical and social cognition in nonhuman primates. A subset of these chimpanzees (n = 146) was tested a second time on a portion of the PCTB tasks as a means of evaluating longitudinal changes in cognition. Cross‐sectional analyses revealed a significant quadratic association between age and cognition with younger and older chimpanzees performing more poorly than middle‐aged individuals. Longitudinal analyses showed that the oldest chimpanzees at the time of the first test showed the greatest decline in cognition, although the effect was mild. The collective data show that chimpanzees, like other nonhuman primates, show age‐related decline in cognition. Further investigations into whether the observed cognitive decline is associated with AD pathologies in chimpanzees would be invaluable in understanding the comparative biology of aging and neuropathology in primates.

中文翻译：

黑猩猩（泛穴居人）认知的年龄相关变化：横断面和纵向分析

黑猩猩是与人类关系最密切的物种，但与年龄相关的大脑和认知变化仍然知之甚少。鉴于最近的证据表明该物种自然会患上阿尔茨海默病（AD）神经病理学，因此缺乏对黑猩猩与年龄相关的认知变化的研究尤其不幸。在这里，我们对 213 只年轻、中年和老年圈养黑猩猩进行了灵长类认知测试电池 (PCTB) 的测试，这是一组评估非人类灵长类动物身体和社会认知的 13 项任务。这些黑猩猩的子集（ n = 146）在 PCTB 任务的一部分上进行了第二次测试，作为评估认知纵向变化的手段。横断面分析显示，年龄和认知之间存在显着的二次关联，年轻和年长的黑猩猩比中年个体表现更差。纵向分析表明，最年长的黑猩猩在第一次测试时表现出最大的认知下降，尽管影响很轻微。集体数据表明，黑猩猩与其他非人类灵长类动物一样，表现出与年龄相关的认知能力下降。进一步研究观察到的黑猩猩认知能力下降是否与 AD 病理有关，对于理解灵长类动物衰老和神经病理学的比较生物学具有无价的价值。

更新日期：2020-11-10

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