Solid cancers progress from primordial lesions through complex interactions between tumor-promoting and anti-tumor immune cell types, ultimately leading to the orchestration of humoral and T cell adaptive immune responses, albeit in an immunosuppressive environment. B cells infiltrating most established tumors have been associated with a dual role: Some studies have associated antibodies produced by tumor-associated B cells with the promotion of regulatory activities on myeloid cells, and also with direct immunosuppression through the production of IL-10, IL-35 or TGF-β. In contrast, recent studies in multiple human malignancies identify B cell responses with delayed malignant progression and coordinated T cell protective responses. This includes the elusive role of Tertiary Lymphoid Structures identified in many human tumors, where the function of B cells remains unknown. Here, we discuss emerging data on the dual role of B cell responses in the pathophysiology of human cancer, providing a perspective on future directions and possible novel interventions to restore the coordinated action of both branches of the adaptive immune response, with the goal of maximizing immunotherapeutic effectiveness.

实体癌从原始病变发展而来，通过促肿瘤和抗肿瘤免疫细胞类型之间复杂的相互作用，最终导致体液和 T 细胞适应性免疫反应的协调，尽管是在免疫抑制环境中。浸润大多数已形成肿瘤的 B 细胞具有双重作用：一些研究将肿瘤相关 B 细胞产生的抗体与促进骨髓细胞的调节活性联系起来，并且还通过产生 IL-10、IL 来直接进行免疫抑制。 -35或TGF-β。相比之下，最近对多种人类恶性肿瘤的研究发现，B 细胞反应具有延迟恶性进展和协调 T 细胞保护反应的作用。这包括在许多人类肿瘤中发现的三级淋巴结构的难以捉摸的作用，其中 B 细胞的功能仍然未知。在这里，我们讨论了有关 B 细胞反应在人类癌症病理生理学中双重作用的新数据，为未来方向和可能的新干预措施提供了展望，以恢复适应性免疫反应两个分支的协调作用，目标是最大限度地发挥 B 细胞反应在人类癌症病理生理学中的双重作用。免疫治疗效果。