Asthma in COVID-19 patients: An extra chain fitting around the neck?,Respiratory Medicine

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Asthma in COVID-19 patients: An extra chain fitting around the neck?
Respiratory Medicine ( IF 3.5 ) Pub Date : 2020-11-11 , DOI: 10.1016/j.rmed.2020.106205
Mohammad H Hussein ₁ , Eman A Toraih ₂ , Abdallah S Attia ₁ , Nicholas Burley ₃ , Allen D Zhang ₃ , Jackson Roos ₃ , August Houghton ₃ , Nedum Aniemeka ₃ , Mahmoud Omar ₁ , Mohamed Aboueisha ₄ , Mohamed A Shama ₁ , Juan Duchesne ₅ , Emad Kandil ₁

Affiliation

Introduction

The novel coronavirus disease 2019 (COVID-19) has rapidly spread across the globe. Pre-existing comorbidities have been found to have a dramatic effect on the disease course. We sought to analyze the effect of asthma on the disease progression and outcomes of COVID-19 patients.

Methods

We conducted a multi-center retrospective study of positively confirmed COVID-19 patients. The primary outcome of interest was in-hospital mortality. Secondary outcomes were the Intensive Care Unit (ICU) admission, intubation, mechanical ventilation, and length of hospital stay.

Results

A total of 502 COVID-19 adult patients (72 asthma and 430 non-asthma cohorts) with mean age of 60.7 years were included in the study. The frequency of asthma in hospitalized cohorts was 14.3%. Univariate analysis revealed that asthma patients were more likely to be obese (75% versus 54.2%, p = 0.001), with a higher frequency of intubation (40.3% versus 27.8%, p = 0.036), and required a longer duration of hospitalization (15.1 ± 12.5 versus 11.5 ± 10.6, p = 0.015). After adjustment, multivariable analysis showed that asthmatic patients were not associated with higher risk of ICU admission (OR = 1.81, 95%CI = 0.98–3.09, p = 0.06), endotracheal intubation (OR = 1.77, 95%CI = 0.99–3.04, p = 0.06) or complications (OR = 1.37, 95%CI = 0.82–2.31, p = 0.23). Asthmatic patients were not associated with higher odds of prolonged hospital length of stay (OR = 1.48, 95%CI = 0.82–2.66, p = 0.20) or with ICU stay (OR = 0.76, 95%CI = 0.28–2.02, p = 0.58). Kaplan-Meier curve showed no significant difference in the overall survival of the two groups (p = 0.65).

Conclusion

Despite the increased prevalence of hospitalization in elder asthmatic COVID-19 patients, after adjustment for other variables, it was neither associated with increased severity nor worse outcomes.

中文翻译：

COVID-19 患者的哮喘：在脖子上安装一条额外的链条？

介绍

新型冠状病毒病 2019 (COVID-19) 已在全球迅速传播。已发现预先存在的合并症对疾病进程有显着影响。我们试图分析哮喘对 COVID-19 患者疾病进展和结局的影响。

方法

我们对 COVID-19 确诊患者进行了多中心回顾性研究。感兴趣的主要结果是院内死亡率。次要结果是重症监护病房 (ICU) 入院、插管、机械通气和住院时间。

结果

该研究共纳入 502 名平均年龄为 60.7 岁的 COVID-19 成年患者（72 名哮喘患者和 430 名非哮喘患者）。住院队列中哮喘的发生率为 14.3%。单变量分析显示，哮喘患者更可能肥胖（75%对54.2%，p = 0.001），插管频率更高（40.3%对27.8%，p = 0.036），并且需要更长的住院时间（ 15.1 ± 12.5对比11.5 ± 10.6，p = 0.015）。调整后，多变量分析显示哮喘患者与入住 ICU 的高风险无关（OR = 1.81，95%CI = 0.98–3.09，p = 0.06），气管插管（OR = 1.77，95%CI = 0.99–3.04，p = 0.06）或并发症（OR = 1.37，95%CI = 0.82–2.31，p = 0.23）。哮喘患者与住院时间延长 (OR = 1.48, 95%CI = 0.82–2.66, p = 0.20) 或入住 ICU (OR = 0.76, 95%CI = 0.28–2.02, p = 0.58）。Kaplan-Meier 曲线显示两组的总生存率无显着差异 ( p = 0.65)。