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Different and common brain signals of altered neurocognitive mechanisms for unfamiliar face processing in acquired and developmental prosopagnosia
Cortex ( IF 3.6 ) Pub Date : 2020-11-11 , DOI: 10.1016/j.cortex.2020.10.017
Ela I Olivares 1 , Ana S Urraca 2 , Agustín Lage-Castellanos 3 , Jaime Iglesias 1
Affiliation  

Neuropsychological studies have shown that prosopagnosic individuals perceive face structure in an atypical way. This might preclude the formation of appropriate face representations and, consequently, hamper effective recognition. The present ERP study, in combination with Bayesian source reconstruction, investigates how information related to both external (E) and internal (I) features was processed by E.C. and I.P., suffering from acquired and developmental prosopagnosia, respectively. They carried out a face-feature matching task with new faces. E.C. showed poor performance and remarkable lack of early face-sensitive P1, N170 and P2 responses on right (damaged) posterior cortex. Although she presented the expected mismatch effect to target faces in the E-I sequence, it was of shorter duration than in Controls, and involved left parietal, right frontocentral and dorsofrontal regions, suggestive of reduced neural circuitry to process face configurations. In turn, I.P. performed efficiently but with a remarkable bias to give “match” responses. His face-sensitive potentials P1–N170 were comparable to those from Controls, however, he showed no subsequent P2 response and a mismatch effect only in the I-E sequence, reflecting activation confined to those regions that sustain typically the initial stages of face processing. Relevantly, neither of the prosopagnosics exhibited conspicuous P3 responses to features acting as primes, indicating that diagnostic information for constructing face representations could not be sufficiently attended nor deeply encoded. Our findings suggest a different locus for altered neurocognitive mechanisms in the face network in participants with different types of prosopagnosia, but common indicators of a deficient allocation of attentional resources for further recognition.



中文翻译:

不同的和常见的大脑信号改变后天性和发育性前瞻性陌生面孔处理的神经认知机制

神经心理学研究表明,患有预后障碍的人会以非典型方式感知面部结构。这可能会阻止形成适当的面部表情,从而妨碍有效的识别。当前的ERP研究与贝叶斯资源重构相结合,研究了EC和IP如何分别处理与外部(E)和内部(I)特征相关的信息,这些信息分别患有获得性和发展性的围手术期。他们用新面孔执行了人脸特征匹配任务。EC表现不佳,右后皮(受损)的早期面部敏感的P1,N170和P2反应明显不足。尽管她向EI序列中的目标脸部提出了预期的失配效果,但持续时间比对照组短,并且涉及左侧顶叶,右额中央和背额区域,提示神经回路减少以处理面部结构。反过来,IP的执行效率很高,但存在明显的偏差,无法给出“匹配”响应。他的脸部敏感电位P1-N170与对照组的相当,但是,他仅在IE序列中没有显示出随后的P2反应和失配效应,反映出激活仅限于那些通常维持脸部处理初始阶段的区域。与此相关的是,这两种假体诊断学都没有表现出对作为素数的特征的明显P3响应,这表明用于构造人脸表示的诊断信息无法得到足够的重视或得到深度编码。

更新日期:2020-12-01
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