Purpose

The physical properties of contact lens care solutions and Eye Drops (ED) may affect initial comfort and dry eye symptomatology in contact lens wearers, although these properties are not always provided by manufacturers. The present study aimed to measure and compare the osmolality and pH of commercially available contact lens care solutions and ED.

Methods

Forty-four solutions were tested (17 lens care solutions and 27 ED) and classified by the presence and/or combination of the viscosity/lubrication-enhancing ingredients. Solution osmolality was obtained with the Fiske 110 osmometer and pH was measured with a micro-pH 2000. Each measurement was taken ten times, following the manufacturer's instructions, while controlling for room temperature and humidity. Differences between the values of the physical properties of the solutions were analysed by type and viscosity/lubrication-enhancing agent subclassification.

Results

Osmolality ranged from 192.6 ± 2.17 to 364.6 ± 2.88 mOsm/Kg, while pH ranged from 6.35 [6.35–6.26] to 7.99 [7.99–8.00]. A significant difference in the osmolality and pH values of contact lens care solutions and ED was found when classified by type or viscosity/lubrication-enhancing agent (ANOVA and Kruskal-Wallis respectively, both p < 0.001).

Conclusions

The physical properties of some contact lens care solutions and ED are not readily available. The osmolality and pH values of various commercially available lens care solutions and ED vary significantly both by type and viscosity/lubrication-enhancing ingredients.

中文翻译：

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市售隐形眼镜护理液和滴眼液的渗透压和 pH 值

目的

隐形眼镜护理液和滴眼液 (ED) 的物理特性可能会影响隐形眼镜佩戴者的初始舒适度和干眼症状，尽管制造商并不总是提供这些特性。本研究旨在测量和比较市售隐形眼镜护理液和 ED 的渗透压和 pH 值。

方法

测试了 44 种溶液（17 种镜片护理液和 27 种 ED）并根据粘度/润滑增强成分的存在和/或组合进行分类。使用 Fiske 110 渗透压计获得溶液渗透压，使用 micro-pH 2000 测量 pH。按照制造商的说明，每次测量进行十次，同时控制室温和湿度。溶液物理性质值之间的差异通过类型和粘度/润滑剂增强剂子分类进行分析。

结果

渗透压范围为 192.6 ± 2.17 至 364.6 ± 2.88 mOsm/Kg，而 pH 范围为 6.35 [6.35-6.26] 至 7.99 [7.99-8.00]。当按类型或粘度/润滑增强剂分类时，隐形眼镜护理液和 ED 的渗透压和 pH 值存在显着差异（分别为方差分析和 Kruskal-Wallis，p < 0.001）。

结论

一些隐形眼镜护理液和 ED 的物理特性并不容易获得。各种市售镜片护理液和 ED 的渗透压和 pH 值因类型和粘度/润滑增强成分而异。