Advances in Colloid and Interface Science ( IF 15.9 ) Pub Date : 2020-11-10 , DOI: 10.1016/j.cis.2020.102316 Mahnaz Amiri 1 , Payam Khazaeli 2 , Ali Salehabadi 3 , Masoud Salavati-Niasari 4
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The present article evaluates the composition and synthesis of hydrogel beads. Hydrogels, owing to their known biocompatibility, are widely used in drug delivery as a host (or drug carrier). Hydrogels, owing to their physical, chemical and biological properties, are popular in many aspects. Hydrogels are crosslinked-hydrophilic polymers and commercialized/synthesized in both natural and synthetic forms. These polymers are compatible with human tissues, therefore can be potentially used for biomedical treatments. Hydrogels in drug delivery offer several points of interest such as sustainability, and sensitivity without any side-effects as compared to traditional methods in this field. Drugs can encapsulate and release continuously into the targets when hydrogels are activated/modified magnetically or by fluorescent materials. It is crucial to develop new crosslinked polymers in terms of “biocompatibility” and “biodegradability” for novel drug delivery platforms. In the event that the accomplishments of the past can be used into the longer terms, it is exceedingly likely that hydrogels with a wide cluster of alluring properties can be synthesized. The current review, offers an updated summary of latest developments in the nanomedicines field as well as nanobased drug delivery systems over broad study of the discovery/ application of nanomaterials in improving both the efficacy of drugs and targeted delivery of them. The challenges/opportunities of nanomedicine in drug delivery also discussed.
Scope of the research
Although several reviews have been published in the field of hydrogels, however many of them have just centralized on the general overviews in terms of “synthesis” and “properties”. The utilization of hydrogels and hydrogel-based composites in vital applications have been achieved a great interest. In this review, our aim is to recap of the key points in the field of hydrogels such as; a) hydrogel nanocomposites, b) magnetic beads, c) biomedical applications, and d) drug delivery. In the same vein, these outlines will be expanded with emphasizing on the boon of magnetic beads and recent developments in this area.
中文翻译：
新型药物递送平台中基于水凝胶珠的纳米复合材料：近期趋势和发展
本文评估了水凝胶珠的组成和合成。水凝胶由于其已知的生物相容性，被广泛用于作为宿主（或药物载体）的药物递送。水凝胶由于其物理、化学和生物学特性，在许多方面都很受欢迎。水凝胶是交联的亲水聚合物，以天然和合成形式商业化/合成。这些聚合物与人体组织相容，因此可用于生物医学治疗。与该领域的传统方法相比，药物输送中的水凝胶提供了几个兴趣点，例如可持续性和敏感性，没有任何副作用。当水凝胶被磁性或荧光材料激活/修饰时，药物可以封装并连续释放到目标中。就新型药物递送平台的“生物相容性”和“生物降解性”而言，开发新型交联聚合物至关重要。如果过去的成就可以长期使用，则极有可能合成具有广泛诱人特性的水凝胶。目前的综述提供了纳米药物领域最新发展的最新总结，以及纳米药物递送系统的最新进展，广泛研究了纳米材料的发现/应用，以提高药物的功效和靶向递送。还讨论了纳米医学在药物递送方面的挑战/机遇。如果过去的成就可以长期使用，则极有可能合成具有广泛诱人特性的水凝胶。目前的综述提供了纳米药物领域最新发展的最新总结，以及纳米药物递送系统的最新进展，广泛研究了纳米材料的发现/应用，以提高药物的功效和靶向递送。还讨论了纳米医学在药物递送方面的挑战/机遇。如果过去的成就可以长期使用，则极有可能合成具有广泛诱人特性的水凝胶。目前的综述提供了纳米药物领域最新发展的最新总结，以及纳米药物递送系统的最新进展，广泛研究了纳米材料的发现/应用，以提高药物的功效和靶向递送。还讨论了纳米医学在药物递送方面的挑战/机遇。通过对纳米材料在提高药物功效和靶向给药方面的发现/应用的广泛研究，对纳米医学领域的最新发展以及基于纳米的药物递送系统进行了更新总结。还讨论了纳米医学在药物递送方面的挑战/机遇。通过对纳米材料在提高药物功效和靶向给药方面的发现/应用的广泛研究，对纳米医学领域的最新发展以及基于纳米的药物递送系统进行了更新总结。还讨论了纳米医学在药物递送方面的挑战/机遇。
研究范围
尽管在水凝胶领域已经发表了几篇评论，但其中许多评论只是集中在“合成”和“性能”方面的总体概述上。水凝胶和水凝胶基复合材料在重要应用中的利用引起了极大的兴趣。在这篇综述中，我们的目标是回顾水凝胶领域的关键点，例如：a) 水凝胶纳米复合材料，b) 磁珠，c) 生物医学应用，以及 d) 药物输送。同样，这些轮廓将通过强调磁珠的好处和该领域的最新发展来扩展。
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