We demonstrate the fabrication of a novel magnetic nanohybrid involving the drug molecule 5-aminolevulinic acid (5-ALA) intercalated Gd-Eu layered rare-earth hydroxide (LRH) coated on magnesium ferrite particles (MgFe₂O₄). The structure, thermostability, morphology, luminescence properties, cytotoxic effect and magnetism are investigated. The 5-ALA intercalated composite may correspond to a monolayered vertical arrangement, and the thermal stability of organics is enhanced after intercalation. The LRH precursor shows red emission of Eu³⁺ and the maximum emission peak of the composite is at 451 nm, corresponding to the blue emission. The detection of drug molecules can be realized through the change of luminescence. The magnetic nanohybrid shows strong magnetic sensitivity, which provides an easy and efficient way to separate 5-ALA-MgFe₂O₄@LGd_0.95H:Eu_0.05 particles from a sol or a suspension system and to carry drugs to targeted locations under an external magnetic field. The cytotoxic effect of MgFe₂O₄@LRH is observed with a sulforhodamine B (SRB) colorimetric assay, which has low cytotoxic effects on selected cells. The fabrication of novel bifunctional drug carriers based on LRH with magnetic and fluorescent properties has potential applications in drug detection and drug delivery.

我们演示了涉及药物分子5-氨基乙酰丙酸（5-ALA）嵌入在铁氧体镁颗粒（MgFe ₂ O ₄）上的Gd-Eu层状稀土氢氧化物（LRH）嵌入的新型磁性纳米复合物的制备。研究了结构，热稳定性，形态，发光性质，细胞毒性作用和磁性。5-ALA插层复合物可以对应于单层垂直排列，并且插层后有机物的热稳定性得到增强。LRH前体显示出Eu ^3+的红色发射复合材料的最大发射峰在451 nm处，对应于蓝色发射。药物分子的检测可以通过改变发光来实现。磁性纳米杂化物显示出强大的磁敏性，这提供了一种简便有效的方法，可从溶胶或悬浮系统中分离5-ALA-MgFe ₂ O ₄ @LGd _0.95 H：Eu _0.05颗粒，并将药物运至外部环境下的目标位置磁场。MgFe ₂ O ₄的细胞毒性作用用磺基罗丹明B（SRB）比色法可观察到@LRH，对选定的细胞具有低细胞毒性作用。基于具有磁性和荧光性质的LRH的新型双功能药物载体的制备在药物检测和药物递送中具有潜在的应用。