Chronic obstructive pulmonary disease (COPD) is a heterogeneous group of lung diseases limiting the airflow due to narrowing of airways, chronic bronchitis and emphysema that leads to difficulties in breathing. Chronic inflammation is another important characteristic of COPD which leads to immune cell infiltration and helps in the alveolar destruction. Pathology of COPD is driven by various environmental and genetic factors. COPD is mainly associated with the inhalation of toxic agents mainly the cigarette smoke. Receptor for advanced glycation end products (RAGE) has emerged as a pattern recognition receptor and is a multiligand receptor expressed moderately in various cells, tissues and highly in the lungs throughout life. RAGE recognizes various ligands produced by cigarette smoke and its role has been implicated in the pathogenesis of COPD. RAGE ligands have been reported to accumulate in the lungs of patients with COPD. RAGE is a membrane receptor but its truncated form i.e. soluble RAGE (sRAGE) mainly functions as a contender of RAGE and inhibits various RAGE dependent cell signalling. Among the various ligands of RAGE, advanced glycation end products (AGEs) are majorly linked with COPD. Accumulated AGE triggers downstream RAGE-AGE axis in COPD. Moreover, RAGE genetics has long been known to play a vital role in the pathology of various airway diseases including COPD and this gene contains an associated locus. A reliable biomarker is needed for the management of this disease. sRAGE has an inverse correlation with the RAGE showed its importance as a valuable marker in COPD. This review is focused on the role of RAGE, sRAGE, RAGE axis and RAGE genetics in COPD.

慢性阻塞性肺疾病 (COPD) 是一组异质性肺部疾病，由于气道狭窄、慢性支气管炎和肺气肿导致呼吸困难而限制气流。慢性炎症是 COPD 的另一个重要特征，它导致免疫细胞浸润并有助于肺泡破坏。COPD的病理学是由各种环境和遗传因素驱动的。COPD 主要与吸入有毒物质有关，主要是香烟烟雾。晚期糖基化终产物 (RAGE) 受体已成为一种模式识别受体，是一种多配体受体，在整个生命过程中在各种细胞、组织和肺部高度表达。RAGE 识别香烟烟雾产生的各种配体，其作用与 COPD 的发病机制有关。据报道，RAGE 配体会在 COPD 患者的肺中积聚。RAGE 是一种膜受体，但其截短形式即可溶性 RAGE (sRAGE) 主要作为 RAGE 的竞争者发挥作用并抑制各种 RAGE 依赖性细胞信号传导。在 RAGE 的各种配体中，晚期糖基化终产物 (AGEs) 主要与 COPD 相关。累积的 AGE 在 COPD 中触发下游 RAGE-AGE 轴。此外，人们早就知道 RAGE 遗传学在包括 COPD 在内的各种气道疾病的病理学中起着至关重要的作用，并且该基因包含相关基因座。需要一种可靠的生物标志物来管理这种疾病。sRAGE 与 RAGE 呈负相关，显示其作为 COPD 有价值标志物的重要性。本综述的重点是 RAGE、sRAGE、RAGE 轴和 RAGE 遗传学在 COPD 中的作用。