The current study prospects the antimicrobial potential of an endophytic fungus Chaetomium globosum which showed a wide spectrum antimicrobial activity against the tested pathogenic microorganisms. This is apparently the first report where Chaetomium globosum as an endophyte from Moringa oleifera showed antimicrobial potential and is optimized for physiochemical parameters to enhance the antimicrobial metabolites production. In the classical optimization yeast peptone dextrose medium, inoculum size of two discs, incubation period of 6 days, production temperature of 25 ºC and pH 7 was best supportive for optimal growth and antimicrobial activity whereas maltose and ammonium nitrate were the best carbon and nitrogen sources, respectively. The statistical optimization resulted in up to 1.33 fold increase in antimicrobial activity. Chloroform was found to be the best extractant. The chloroformic extract showed minimum inhibitory concentration ranging from 0.05 to 5 mg/ml and its microbicidal nature was established by viable cell count studies. The efficacy of the extract was also established in terms of post antibiotic effect which ranged from 2 to 20 h. The chloroformic extract exhibited the good antibiofilm potential and was also found to be biosafe. The clinical relevance of the study was justified as it showed good antimicrobial efficacy against some resistant clinical isolates, too.

当前的研究展望了一种内生真菌球毛龟（Chaetomium globosum）的抗菌潜力，该细菌对被测病原微生物表现出广谱的抗菌活性。这显然是第一份报道，即球果白皮作为来自辣木的内生植物。具有抗微生物潜力，并针对理化参数进行了优化，以增强抗微生物代谢产物的产生。在经典优化的酵母蛋白ept葡萄糖培养基中，接种量为两个圆盘，孵育时间为6天，生产温度为25ºC，pH为7是最佳生长和抗菌活性的最佳支持，而麦芽糖和硝酸铵是最佳碳和氮源， 分别。统计优化使抗菌活性提高了1.33倍。发现氯仿是最好的萃取剂。氯仿提取物的​​最低抑菌浓度范围为0.05至5 mg / ml，其杀微生物性质是通过活细胞计数研究确定的。提取物的功效还根据2-20小时的抗生素后效应确定。氯仿提取物表现出良好的抗生物膜潜力，也被发现具有生物安全性。该研究的临床相关性是合理的，因为它对某些耐药的临床分离株也显示出良好的抗菌功效。