Mammalian reproduction is a highly regulated process that can be distorted following exposure to synthetic antimicrobial preservatives like butylparaben (BP). Besides, studies have not investigated the potential antioxidant effects of turmeric on BP-provoked reprotoxicity. The present research was planned on prepubertal mice, orally treated with BP (150 μg/g body weight/day) with and without Curcuma longa (turmeric) (400 μg/mice/day) from postnatal day 35 to 65 routinely. Results showed an insignificant reduction in body weight of both sexes but contrary to these, gonadal weight increased significantly in PB-exposed mice. Additionally, elevated levels of follicle-stimulating hormone and luteinizing hormone while decreased estrogen levels were observed in BP-treated females against control. Sperm count and motility were disturbed, coupled with abnormal sperm morphology in BP-intoxicated group. These findings were synchronized with a decreased testosterone levels in the same group as compared with control. The follicular count revealed reduction in the number of antral follicles while an increase in empty follicles. The BP also significantly increased lipid peroxidation and decreased glutathione content, superoxide dismutase, and catalase activities, while the morphometric, biochemical, and histological deviations were less pronounced in the group, which was co-administered with BP and turmeric. Results indicated that turmeric has antioxidant potential to protect BP-induced oxidative stress and reprotoxicity in mice.

哺乳动物的繁殖是受到严格控制的过程，如果暴露于对羟基苯甲酸丁酯（BP）等合成抗微生物防腐剂中，哺乳动物的繁殖就会受到干扰。此外，研究还没有研究姜黄对BP引起的生殖毒性的潜在抗氧化作用。本研究计划在青春期前的小鼠中进行，口服含或不含姜黄素的BP（150μg/ g体重/天）（姜黄）（400微克/小鼠/天）从产后第35天到第65天常规进行。结果表明，男女体重均无明显下降，但与此相反，暴露于PB的小鼠的性腺重量显着增加。此外，与对照相比，在经BP治疗的女性中，观察到促卵泡激素和促黄体生成素水平升高，而雌激素水平降低。BP中毒组精子数量和运动受到干扰，并伴有精子形态异常。与对照组相比，同一组中这些发现与睾丸激素水平降低同步。卵泡计数显示窦性卵泡数目减少，而空卵泡数目增加。BP还显着增加了脂质过氧化作用，并降低了谷胱甘肽含量，超氧化物歧化酶和过氧化氢酶活性，而在形态学，生化和组织学方面的差异在该组中较不明显，该组与BP和姜黄合用。结果表明，姜黄具有抗氧化作用，可以保护BP诱导的小鼠氧化应激和再毒性。