Bone plates are used to treat bone fractures by stabilizing the fracture site and allowing treatments to take place. Mechanical properties of the applied bone plate determine the stability of the fracture site and affect the endochondral ossification process and the healing performance. In recent years, biodegradable bone plates have been used in demand for the elimination of a second surgery to remove the plate. The degradation of these plates into the body environment is commonly accompanied by alterations in the mechanical properties of the bone plate and a shift in the healing performance of the bone. In the present study, the effects of using biodegradable plates with various elastic moduli and degradation patterns, including linear and nonlinear, on the healing process are investigated. A three-dimensional finite element model of the radius bone along with a mechano-regulation theory was used to study the healing performance. Two mechanical stimuli of octahedral shear strain and interstitial fluid flow are considered as the propelling factors of healing. The results of this study indicated that increasing the bone plate's initial elastic modulus accelerates the healing process. However, by increasing the initial Young's modulus of the plate more than 100 GPa, no noticeable alteration is observed. The degradation time period of the plate was seen to be directly related to the speed of the healing process. It is shown, however, that by increasing the degradation time period to more than 8 weeks, the healing performance remains almost unchanged. The results of this work showed that the application of plates with a high enough initial elastic modulus and degradation period can prevent the healing process from decelerating.

中文翻译：

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使用双相机械调节理论，可生物降解骨板的降解模式对愈合过程的影响。

骨板用于通过稳定骨折部位并允许进行治疗来治疗骨折。所应用接骨板的机械性能决定了骨折部位的稳定性并影响软骨内骨化过程和愈合性能。近年来，可生物降解骨板已被用于消除二次手术以去除骨板的需求。这些骨板在身体环境中的降解通常伴随着骨板机械性能的改变和骨愈合性能的转变。在本研究中，研究了使用具有各种弹性模量和降解模式（包括线性和非线性）的可生物降解板对愈合过程的影响。桡骨的三维有限元模型以及机械调节理论用于研究愈合性能。八面体剪切应变和间质流体流动这两个机械刺激被认为是愈合的推动因素。这项研究的结果表明，增加骨板的初始弹性模量会加速愈合过程。然而，通过增加板的初始杨氏模量超过 100 GPa，没有观察到明显的变化。板的降解时间段被认为与愈合过程的速度直接相关。然而，结果表明，通过将降解时间增加到 8 周以上，愈合性能几乎保持不变。