Cohousing of sick with healthy or treated animals is based on the concept of sharing an intestinal ecosystem and coprophagy, the consumption of feces, which includes sharing of the microbiome and of active drug metabolites secreted in the feces or urine. To develop a model for short-term cohousing, enabling the study of the effect of sharing an ecosystem on inflammatory states. To determine the impact of cohousing of sick and healthy mice on the immune-mediated disorders, mice injected with concanavalin A (ConA) were cohoused with healthy or sick mice or with steroid-treated or untreated mice. To determine the effect of cohousing on acetaminophen (APAP)-induced liver damage, APAP-injected mice were cohoused with N-acetyl-cysteine (NAC)-treated or untreated mice. In the ConA-induced immune-mediated hepatitis model, cohousing of sick with healthy mice was associated with the alleviation of liver damage in sick animals. Similarly, a significant decrease in serum ALT was noted in ConA-injected mice kept in the same cage as ConA-injected mice treated with steroids. A trend for reduction in liver enzymes in APAP-injected mice was observed upon cohousing with NAC-treated animals. Cohousing of sick mice with healthy or treated mice ameliorated the immune-mediated inflammatory state induced by ConA and APAP. These models for liver damage can serve as biological systems for determining the effects of alterations in the ecosystem on the immune system.

中文翻译：

---

将生病的小鼠与健康的或经过治疗的小鼠短期同住可减轻炎症反应和肝损伤。

将生病的动物与健康或治疗过的动物同住是基于共享肠道生态系统和食粪的概念，粪便的消耗，包括共享粪便或尿液中分泌的微生物组和活性药物代谢物。开发短期共住模型，研究共享生态系统对炎症状态的影响。为了确定生病和健康小鼠同住对免疫介导疾病的影响，注射了刀豆球蛋白 A (ConA) 的小鼠与健康或生病的小鼠或类固醇治疗或未治疗的小鼠共养。为了确定同住对对乙酰氨基酚 (APAP) 诱导的肝损伤的影响，将注射 APAP 的小鼠与 N-乙酰半胱氨酸 (NAC) 处理或未处理的小鼠共养。在 ConA 诱导的免疫介导的肝炎模型中，将患病小鼠与健康小鼠同住与减轻患病动物的肝损伤有关。类似地，在与用类固醇治疗的 ConA 注射小鼠保持在同一笼子中的 ConA 注射小鼠中，注意到血清 ALT 显着降低。在与 NAC 治疗的动物共居后，观察到注射 APAP 的小鼠肝酶减少的趋势。将生病的小鼠与健康或治疗过的小鼠同住可改善由 ConA 和 APAP 诱导的免疫介导的炎症状态。这些肝损伤模型可以作为确定生态系统变化对免疫系统影响的生物系统。在与 NAC 治疗的动物共居后，观察到注射 APAP 的小鼠肝酶减少的趋势。将生病的小鼠与健康或治疗过的小鼠同住可改善由 ConA 和 APAP 诱导的免疫介导的炎症状态。这些肝损伤模型可以作为确定生态系统变化对免疫系统影响的生物系统。在与 NAC 治疗的动物共居后，观察到注射 APAP 的小鼠肝酶减少的趋势。将生病的小鼠与健康或治疗过的小鼠同住可改善由 ConA 和 APAP 诱导的免疫介导的炎症状态。这些肝损伤模型可以作为确定生态系统变化对免疫系统影响的生物系统。