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Discovery and Development of Inflammatory Inhibitors from 2-Phenylchromonone (Flavone) Scaffolds.
Current Topics in Medicinal Chemistry ( IF 2.9 ) Pub Date : 2020-01-01 , DOI: 10.2174/1568026620666200924115611
Chen Xu 1 , Meng-Yuan Fang 1 , Ke Wang 2 , Jing Liu 3, 4 , Guang-Ping Tai 3 , Zhao-Ting Zhang 2 , Ban-Feng Ruan 1, 3
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Flavonoids are compounds based on a 2-phenylchromonone scaffold. Flavonoids can be divided into flavonoids, flavonols, dihydroflavones, anthocyanins, chalcones and diflavones according to the oxidation degree of the central tricarbonyl chain, the connection position of B-ring (2-or 3-position), and whether the tricarbonyl chain forms a ring or not. There are a variety of biological activities about flavonoids, such as anti-inflammatory activity, anti-oxidation and anti-tumor activity, and the antiinflammatory activity is apparent. This paper reviews the anti-inflammatory activities and mechanisms of flavonoids and their derivatives reported in China and abroad from 2011 till date (2011-2020), in order to find a good drug scaffold for the study of anti-inflammatory activities.

中文翻译:

从 2-苯基色酮(黄酮)支架中发现和开发炎症抑制剂。

类黄酮是基于 2-苯基色酮骨架的化合物。黄酮类化合物根据中心三羰基链的氧化程度、B环的连接位置(2-位或3-位)以及三羰基链是否形成一个环,可分为黄酮类、黄酮醇类、二氢黄酮类、花青素类、查耳酮类和二黄酮类。响与否。黄酮类化合物具有多种生物活性,如抗炎活性、抗氧化活性和抗肿瘤活性,抗炎活性明显。本文综述了2011年至今(2011-2020年)国内外报道的黄酮类及其衍生物的抗炎活性及其作用机制,以期为研究抗炎活性寻找一种良好的药物支架。
更新日期:2020-09-24
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