Inflammasomes are multiprotein complexes of the innate immune system. Their activation leads to robust secretion of exosomes. In this issue, Wozniak et al. (2020. J. Cell Biol. https://doi.org/10.1083/jcb.201912074) reveal a connection between inflammasome-mediated cleavage of Rab-interacting lysosomal protein (RILP) and sequence-specific loading of miRNAs into exosomes.

中文翻译：

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炎症小体：外泌体 miRNA 加载发挥作用

炎症小体是先天免疫系统的多蛋白复合物。它们的激活导致外泌体的大量分泌。在本期中，沃兹尼亚克等人。(2020. J. Cell Biol. https://doi.org/10.1083/jcb.201912074) 揭示了炎症小体介导的 Rab 相互作用溶酶体蛋白 (RILP) 裂解与将 miRNA 序列特异性加载到外泌体中之间的联系。