Design, Synthesis, Physical Properties and Indoleamine 2, 3-Dioxygenase 1 Inhibitory Activity of Substitued Indole Derivatives with N-H, N-Metohymethyl, or N-Mehylthiomethyl Group toward Fragment-Based Drug Discovery,Heterocycles

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Design, Synthesis, Physical Properties and Indoleamine 2, 3-Dioxygenase 1 Inhibitory Activity of Substitued Indole Derivatives with N-H, N-Metohymethyl, or N-Mehylthiomethyl Group toward Fragment-Based Drug Discovery
Heterocycles ( IF 0.8 ) Pub Date : 2020-11-09 , DOI: 10.3987/com-20-s(k)35
Mitsuhiro Arisawa , Kenta Hayami , Yuichi Kuboki , Katsumi Ohta , Bangzhong Lin , Megumi Fumimoto , Kazuto Nunomura , Jun-Ichi Haruta , Hiromichi Fujioka , Akira Asai , Kenichi Murai

We designed and prepared N-H, N-CH2OMe(MOM), and N-CH2SMe (MTM) forms of various substituted indoles, using a docking study, as a small fragment library toward fragment-based drug discovery (FBDD) and evaluated their indoleamine 2, 3-dioxygenase 1 (IDO1) inhibitory activities and physical properties.

中文翻译：

设计，合成，物理性质和吲哚胺2、3-二加氧酶1对具有NH，N-甲基甲基或N-甲基硫代甲基的吲哚衍生物对基于片段的药物发现的抑制活性

我们使用对接研究设计并制备了各种取代吲哚的N -H，N -CH 2 OMe（MOM）和N -CH 2 SMe（MTM）形式，作为针对基于片段的药物发现（FBDD）的小片段库）并评估了它们的吲哚胺2、3-双加氧酶1（IDO1）的抑制活性和物理性质。

更新日期：2020-11-09

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