A series of N-(1,3-benzothiazole-2-yl)-2(pyridine-3-ylformohydrazido acetamide derivatives have been synthesized by facile and efficient conventional method. The structures of the compounds have been elucidated with the aid of elemental analysis, IR, ESI-MS, and ¹H and ¹³C NMR spectral data. Molecular docking revealed that synthesized derivatives and target proteins are actively involved in the binding pattern and had a significant correlation with biological activity. Molecular dynamics studies have also been performed and ADME parameters for the synthesized compounds determined. Biological evaluation of all synthesized compounds have been carried out in vitro for their antibacterial, antituberculosis and antifungal efficacy against various bacterial and fungal strains and H₃₇Rv. The different studies indicate that newly synthesized compounds possess moderate to good biological activities.

中文翻译：

---

新型N-（1,3-苯并噻唑-2-基）-2-（吡啶-3-基甲酰肼基）乙酰胺衍生物的合成，对接研究和生物学评价

通过简便有效的常规方法合成了一系列N-（1,3-苯并噻唑-2-基）-2（吡啶-3-基甲酰肼基乙酰胺）衍生物，并通过元素分析阐明了其结构。 ，IR，ESI-MS以及¹ H和¹³ C NMR光谱数据；分子对接表明合成的衍生物和目标蛋白积极参与结合模式，并与生物活性显着相关；还进行了分子动力学研究和确定了合成化合物的ADME参数，所有合成化合物均已在体外进行了生物学评估具有抗各种细菌和真菌和H ₃₇ Rv的抗菌，抗结核和抗真菌功效。不同的研究表明，新合成的化合物具有中等至良好的生物学活性。