Indole – a promising pharmacophore in recent antiviral drug discovery,RSC Medicinal Chemistry

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Indole – a promising pharmacophore in recent antiviral drug discovery
RSC Medicinal Chemistry ( IF 4.1 ) Pub Date : 2020-11-06 , DOI: 10.1039/d0md00288g
Atukuri Dorababu ₁

Affiliation

The bicyclic molecule indole has been in the limelight because of its numerous pharmacological potencies. It is used as an excellent scaffold in drug discovery of medicinal drugs such as antimicrobials, anticancer agents, antihypertensives, anti-proliferative agents and anti-inflammatory agents. In spite of its diverse therapeutic activity, it is used as a key pharmacophore in synthesizing the most potent biological agents. Besides, viral infections are ubiquitous and their prevention and cure have become a great challenge. In this regard, the design of indole-containing antiviral drugs is accomplished to combat viral infections. A lot of research is being carried out towards antiviral drug discovery by many researchers round the clock. Herein, the antiviral activity of recently discovered indole scaffolds is compiled and critically evaluated to give a meaningful summary. In addition, the structure–activity relationship of remarkable antiviral agents is discussed. Also, the structural motifs attributed to noteworthy antiviral properties are highlighted to guide future antiviral research.

中文翻译：

吲哚——最近抗病毒药物发现中一种有前途的药效团

双环分子吲哚因其众多的药理功效而备受关注。它在抗菌剂、抗癌剂、抗高血压剂、抗增殖剂和抗炎剂等药物的药物发现中用作优秀的支架。尽管其具有多种治疗活性，但它仍被用作合成最有效的生物制剂的关键药效团。此外，病毒感染普遍存在，防治成为巨大挑战。就此而言，完成了含吲哚抗病毒药物的设计以对抗病毒感染。许多研究人员正在昼夜不停地进行大量研究，以发现抗病毒药物。在此，对最近发现的吲哚支架的抗病毒活性进行了编译和严格评估，以给出有意义的总结。此外，还讨论了重要抗病毒药物的结构-活性关系。此外，还强调了值得注意的抗病毒特性的结构基序，以指导未来的抗病毒研究。

更新日期：2020-11-09

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