Propolis is a honeybee product displaying an anti-inflammatory, antimicrobial, and antioxidant effect on several tested animal models. Curcumin a polyphenol extracted from turmeric that gained interest as a potentially safe and inexpensive treatment for kidney diseases. The present study aimed to compare the protective effects of curcumin and propolis on endotoxemia-induced renal dysfunction. Sepsis induction caused a marked decline in renal GSH, GPx, and GR, as well as antioxidant enzyme activities; CAT and SOD. Elevation in LPO, NO, IL-1β, and PGE2 contents were observed as well. A marked induction in Bax contents, Bax\Bcl2 ratio, accompanied by activation of NF-kB in the kidney of sepsis-induced rats was reported. However, Prop pretreatment of endotoxemic rats was effective in controlling the depletion of renal GSH content and its correlated enzymes; Cur was more potent in maintaining the renal CAT and SOD contents, as well as, dimensioning LPO content. Despite the renal inflammatory marker IL-1β, PGE2, NO contents, Bax\Bcl2 ratio, and NF-kB activation were greatly reduced by both curcumin and propolis, only Cur pretreatment attenuated NF-kB activation in kidney tissue of septic rat. Though pretreatment of either Cur or Prop to septic rats protected their kidneys against oxidation, inflammation, and apoptosis status, Cur pretreatment was superior in protecting rats’ kidney after sepsis induction.

中文翻译：

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姜黄素和蜂胶对败血症诱导的成年雄性大鼠肾脏氧化应激，炎症和细胞凋亡的比较

蜂胶是一种蜜蜂产品，对几种经过测试的动物模型均具有抗炎，抗微生物和抗氧化作用。姜黄素是一种从姜黄中提取的多酚，作为一种潜在的安全且廉价的肾脏疾病治疗方法而受到关注。本研究旨在比较姜黄素和蜂胶对内毒素血症引起的肾功能不全的保护作用。脓毒症的诱导导致肾脏GSH，GPx和GR以及抗氧化酶活性显着下降。CAT和SOD。还观察到LPO，NO，IL-1β和PGE2含量升高。据报道，脓毒症诱导的大鼠肾脏中Bax含量，Bax \ Bcl2比显着诱导，并伴随着NF-kB的活化。然而，内毒素血症大鼠的道具预处理可有效控制肾脏GSH含量及其相关酶的消耗。Cur在保持肾脏CAT和SOD含量以及确定LPO含量方面更有效。尽管姜黄素和蜂胶均显着降低了肾脏炎症标记物IL-1β，PGE2，NO含量，Bax \ Bcl2比和NF-kB活化，但只有Cur预处理才能减弱脓毒症大鼠肾脏组织中的NF-kB活化。尽管对脓毒症大鼠进行Cur或Prop预处理可保护其肾脏免受氧化，炎症和细胞凋亡状态的影响，但Cur预处理在脓毒症诱发后保护大鼠肾脏方面具有优势。姜黄素和蜂胶均可显着降低NO含量，Bax \ Bcl2比和NF-kB活化，只有Cur预处理可减弱脓毒症大鼠肾脏组织中的NF-kB活化。尽管对脓毒症大鼠进行Cur或Prop预处理可保护其肾脏免受氧化，炎症和细胞凋亡状态的影响，但Cur预处理在脓毒症诱发后保护大鼠肾脏方面具有优势。姜黄素和蜂胶均可显着降低NO含量，Bax \ Bcl2比和NF-kB活化，只有Cur预处理可减弱脓毒症大鼠肾脏组织中的NF-kB活化。尽管对脓毒症大鼠进行Cur或Prop预处理可保护其肾脏免受氧化，炎症和细胞凋亡状态的影响，但Cur预处理在脓毒症诱发后保护大鼠肾脏方面具有优势。