Artemisia vulgaris commonly known as “mugwort” is a very important medicinal plant which is used widely for the treatment of various ailments traditionally. The present studies aimed to conduct preliminary phytochemical screening and evaluate antioxidants and analgesic activities of leaves extract. Phytochemical screening showed the presence of saponins, glycosides, flavanoids, protein, triterpenoids in leaves extract. In DPPH, percentage inhibition of the scavenging activity (68.06%) by the extract in comparison with ascorbic acid (93.53%) at 60 μg/ml while in reducing power assay, the result shown the reducing power increases with the increase of concentration as (0.13 ± 0.02), (0.27 ± 0.03), (0.42 ± 0.03), (0.62 ± 0.05), (0.79 ± 0.02), (0.95 ± 0.05) at concentration of 5, 10, 15, 30, 60 and 100 μg/ml respectively. The evaluation of analgesic activities revealed that at the dose of 200 and 400 mg/kg of the extract showed significantly inhibited the writhing response induced by acetic acid by 8.60% and 32.03% comparatively with indomethacin at a dose of 10 mg/kg b. wt. exhibited 56.87% inhibition. Whereas, in the tail immersion methods, at the dose of 400 mg/kg b. wt. was showed higher deflexion value as 3.40 ± 0.300, while 200 mg/kg b. wt. was resulted at 2.90 ± 0.200 value in dose dependent manner at the maximum time of the studies (60 min). Comparatively, the reference drug indomethacin at dose 10 mg/kg b. wt. has shown the highest deflexion value (5.134 ± 0.351). This finding concludes that the methanolic leaves extract has a potent antioxidants and analgesic activities and it could be attributed to the presence of flavonoids, triterpenoids, saponin, glycosides and proteins. A further study is required to find out the novel bioactive compound of Artemisia vulgaris L. which can lead more effective in various biological activities.

中文翻译：

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蒿叶片甲醇提取物的植物化学和药理作用。

俗称艾蒿（Artemisia vulgaris）是一种非常重要的药用植物，传统上被广泛用于治疗各种疾病。本研究旨在进行初步的植物化学筛选，并评估叶提取物的抗氧化剂和止痛活性。植物化学筛选显示叶提取物中存在皂苷，糖苷，类黄酮，蛋白质，三萜类化合物。在DPPH中，与60μg/ ml的抗坏血酸（93.53％）相比，提取物抑制清除活性的百分比（68.06％），而在还原力测定中，结果表明还原力随浓度的增加而增加，为（在浓度为5、10、15、15、30、60和100μg/ g的情况下为（0.13±0.02），（0.27±0.03），（0.42±0.03），（0.62±0.05），（0.79±0.02），（0.95±0.05）毫升。对镇痛活性的评估表明，在剂量为200和400 mg / kg的提取物中，与吲哚美辛的剂量为10 mg / kg b相比，显着抑制了乙酸诱导的扭体反应，分别为8.60％和32.03％。重量 表现出56.87％的抑制作用。而在尾部浸没法中，剂量为400 mg / kg b。重量 表现出较高的挠度值，为3.40±0.300，而200 mg / kg b。重量 在研究的最大时间（60分钟）以剂量依赖性的方式得到2.90±0.200值。比较而言，参考药物消炎痛的剂量为10 mg / kg b。重量 显示出最高的挠度值（5.134±0.351）。这一发现表明，甲醇叶提取物具有有效的抗氧化剂和止痛活性，这可能归因于类黄酮，三萜类，皂苷，糖苷和蛋白质。需要进行进一步的研究以发现新的寻常蒿的生物活性化合物，该化合物可以在各种生物活性中发挥更有效的作用。