Diabetes is widely recognized as associated with several structural and functional liver, kidney, and heart abnormalities. Therefore, the present study was conducted to evaluate the protective effect of peel extracts of Irvingia wombolu against diabetes complications. Diabetes was induced by intravenous administration of streptozotocin (STZ) (50 mg/kg) through the right jugular vein on rats and animals with blood glucose values of at least 250 mg/dl received orally aqueous extract of peel (AEP), hydroethanolic extract of peel (HEP), tolbutamide and DMSO 10%. Their effects on the concentration of blood glucose, total cholesterol, HDL-C, LDL-C, triglycerides, malondialdehyde (MDA) and activities of catalase (CAT), reduced glutathione (GSH), superoxide dismutase (SOD), aspartate aminotransferase (AST), and alanine aminotransferase (ALT) in diabetic and normal rats were investigated using standard methods. Twenty-one days of treatment with AEP and HEP at a dose of 400 mg/kg significantly (P < 0,05) reduced the fasting blood glucose to a point of reaching normal value. The antihyperlipidemic assessment of extracts revealed a significant (P < 0,05) decrease in total cholesterol, triglycerides, LDL levels, and a significant (P < 0,05) increase in HDL level in the plasma of treated diabetic rats. Furthermore, plasma biomarkers of liver and kidney dysfunction were significantly reduced in treated diabetic rats. We also observed increased activities of catalase, SOD, and reduced glutathione in diabetic treated rats. The present findings suggest that AEP and HEP have a protective effect on liver, kidney, and heart in experimental diabetic rats which can be beneficial in the management of diabetes and its complications.

中文翻译：

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欧文氏果皮提取物对链脲佐菌素诱导的糖尿病大鼠代谢紊乱的保护作用

糖尿病被广泛认为与肝，肾和心脏的几种结构和功能异常有关。因此，本研究旨在评价欧文氏果皮提取物对糖尿病并发症的保护作用。通过右颈静脉对大鼠和动物的血糖值至少为250 mg / dl静脉内施用链脲佐菌素（STZ）（50 mg / kg）诱发糖尿病，口服果皮水提取物（AEP），皮（HEP），甲苯磺丁酰胺和DMSO 10％。它们对血糖，总胆固醇，HDL-C，LDL-C，甘油三酸酯，丙二醛（MDA）和过氧化氢酶（CAT），还原型谷胱甘肽（GSH），超氧化物歧化酶（SOD），天冬氨酸转氨酶（AST）活性的影响），使用标准方法研究了糖尿病和正常大鼠中的丙氨酸和丙氨酸氨基转移酶（ALT）。使用AEP和HEP剂量为400 mg / kg的治疗21天显着（P <0.05）将空腹血糖降至正常水平。提取物的抗高血脂评估显示，治疗的糖尿病大鼠血浆中总胆固醇，甘油三酸酯，LDL水平显着降低（P <0.05），HDL水平显着提高（P <0.05）。此外，在治疗的糖尿病大鼠中，肝和肾功能障碍的血浆生物标志物显着降低。我们还观察到在糖尿病治疗的大鼠中过氧化氢酶，SOD的活性增加和谷胱甘肽减少。目前的发现表明，AEP和HEP对肝脏，肾脏，