Background: N-acetyl-cysteine (NAC) has shown widespread utility in different psychiatric disorders, including a beneficial role in schizophrenic patients. Although the replenishment of glutathione and the antioxidant activity of NAC have been suggested as the mechanisms that improve such a wide range of disorders, none seems to be sufficiently specific to explain these intriguing effects. A sensitive cysteine proteome is emerging as a functional and structural network of interconnected Sensitive Cysteine-containing Proteins (SCCPs) that together with reactive species and the cysteine/ glutathione cycles can regulate the bioenergetic metabolism, the redox homeostasis and the cellular growth, differentiation and survival, acting through different pathways that are regulated by the same thiol radical in cysteine residues.

背景：N-乙酰半胱氨酸（NAC）在不同的精神疾病中已显示出广泛的用途，包括在精神分裂症患者中发挥有益作用。尽管谷胱甘肽的补充和NAC的抗氧化活性已被认为是改善如此广泛疾病的机制，但似乎还没有足够的特异性来解释这些有趣的作用。敏感的半胱氨酸蛋白质组正在作为相互连接的敏感半胱氨酸蛋白（SCCP）的功能和结构网络出现，与反应性物种和半胱氨酸/谷胱甘肽循环一起可以调节生物能代谢，氧化还原稳态以及细胞生长，分化和存活，通过半胱氨酸残基中相同硫醇自由基调节的不同途径起作用。