Objective:

To test our hypothesis that individuals with ADHD would exhibit reduced resiliency to subconcussive head impacts induced by ten soccer headings.

Method:

We conducted a case-control intervention study in 51 adults (20.6 ± 1.7 years old). Cognitive assessment, using ImPACT, and plasma levels of neurofilament-light (NF-L), Tau, glial-fibrillary-acidic protein (GFAP), and ubiquitin-C-terminal hydrolase-L1 (UCH-L1) were measured.

Results:

Ten controlled soccer headings demonstrated ADHD-specific transient declines in verbal memory function. Ten headings also blunted learning effects in visual memory function in the ADHD group while the non-ADHD counterparts improved both verbal and visual memory functions even after ten headings. Blood biomarker levels of the ADHD group were sensitive to the stress induced by ten headings, where plasma GFAP and UCH-L1 levels acutely increased after 10 headings. Variance in ADHD-specific verbal memory decline was correlated with increased levels of plasma GFAP in the ADHD group.

Conclusions:

These data suggest that ADHD may reduce brain tolerance to repetitive subconcussive head impacts.

中文翻译：

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ADHD 可能与对急性亚脑震荡头部撞击的耐受性降低有关：一项试点病例对照干预研究

 客观的：

为了检验我们的假设，即患有多动症的人对 10 次足球头球引起的亚脑震荡头部撞击的弹性会降低。

 方法：

我们对 51 名成年人（20.6 ± 1.7 岁）进行了病例对照干预研究。使用 ImPACT 进行认知评估，并测量神经丝轻链 (NF-L)、Tau、胶质纤维酸性蛋白 (GFAP) 和泛素 C 末端水解酶 L1 (UCH-L1) 的血浆水平。

 结果：

十个受控制的足球头球显示出 ADHD 特异性的言语记忆功能短暂下降。十个标题也削弱了多动症组视觉记忆功能的学习效果，而非多动症组即使在十个标题之后，言语和视觉记忆功能也得到了改善。 ADHD 组的血液生物标志物水平对 10 次标题引起的压力敏感，其中血浆 GFAP 和 UCH-L1 水平在 10 次标题后急剧增加。 ADHD 组中 ADHD 特异性言语记忆下降的差异与血浆 GFAP 水平升高相关。

 结论：

这些数据表明，多动症可能会降低大脑对重复性头部震荡的耐受力。