MicroRNAs (miRNAs) regulate progression of different cancers. Nevertheless, there is limited information regarding the role of miR-106a-5p in renal cell carcinoma (RCC). Herein, we demonstrate that miR-106a-5p levels are drastically decreased in clear cell RCC (ccRCC) tissues and cell lines, which subsequently contribute to a poor patient overall survival and a high tumor stage. By screening and analyzing, we found that miR-106a-5p directly targets the 3-UTR of the VEGFA mRNA and led to a decrease in VEGFA. This process is important for tumor cells’ growth and colony formation, and overexpression of miR-106a-5p can especially kill kidney tumor cells. Therefore, our data reveal that miR-106a-5p functions as a tumor suppressor by regulating VEGFA and ccRCC may be susceptible to miR-106a-5p therapy.

中文翻译：

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miR-106a-5p 通过靶向肾细胞癌中的 VEGFA 发挥肿瘤抑制剂的作用

MicroRNAs (miRNAs) 调节不同癌症的进展。然而，关于 miR-106a-5p 在肾细胞癌 (RCC) 中的作用的信息有限。在此，我们证明 miR-106a-5p 水平在透明细胞 RCC (ccRCC) 组织和细胞系中急剧下降，随后导致患者总体生存率低和肿瘤分期高。通过筛选分析，我们发现miR-106a-5p直接靶向VEGFA mRNA的3 - UTR，导致VEGFA降低。这个过程对肿瘤细胞的生长和集落形成很重要，miR-106a-5p的过表达尤其可以杀死肾肿瘤细胞。因此，我们的数据显示 miR-106a-5p 通过调节 VEGFA 和 ccRCC 发挥肿瘤抑制作用，可能对 miR-106a-5p 治疗敏感。