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Ethnobotany and the Role of Plant Natural Products in Antibiotic Drug Discovery
Chemical Reviews ( IF 51.4 ) Pub Date : 2020-11-09 , DOI: 10.1021/acs.chemrev.0c00922
Gina Porras 1 , François Chassagne 1 , James T Lyles 1 , Lewis Marquez 2 , Micah Dettweiler 3 , Akram M Salam 2 , Tharanga Samarakoon 4 , Sarah Shabih 1 , Darya Raschid Farrokhi 1 , Cassandra L Quave 1, 2, 3, 4
Affiliation  

The crisis of antibiotic resistance necessitates creative and innovative approaches, from chemical identification and analysis to the assessment of bioactivity. Plant natural products (NPs) represent a promising source of antibacterial lead compounds that could help fill the drug discovery pipeline in response to the growing antibiotic resistance crisis. The major strength of plant NPs lies in their rich and unique chemodiversity, their worldwide distribution and ease of access, their various antibacterial modes of action, and the proven clinical effectiveness of plant extracts from which they are isolated. While many studies have tried to summarize NPs with antibacterial activities, a comprehensive review with rigorous selection criteria has never been performed. In this work, the literature from 2012 to 2019 was systematically reviewed to highlight plant-derived compounds with antibacterial activity by focusing on their growth inhibitory activity. A total of 459 compounds are included in this Review, of which 50.8% are phenolic derivatives, 26.6% are terpenoids, 5.7% are alkaloids, and 17% are classified as other metabolites. A selection of 183 compounds is further discussed regarding their antibacterial activity, biosynthesis, structure–activity relationship, mechanism of action, and potential as antibiotics. Emerging trends in the field of antibacterial drug discovery from plants are also discussed. This Review brings to the forefront key findings on the antibacterial potential of plant NPs for consideration in future antibiotic discovery and development efforts.

中文翻译:


民族植物学和植物天然产物在抗生素药物发现中的作用



抗生素耐药性危机需要创造性和创新性的方法,从化学鉴定和分析到生物活性评估。植物天然产物 (NP) 是抗菌先导化合物的一个有前景的来源,可以帮助填补药物发现渠道,以应对日益严重的抗生素耐药性危机。植物纳米粒子的主要优势在于其丰富而独特的化学多样性、其在全球范围内的分布和易于获取、其多种抗菌作用模式以及其分离植物提取物已被证实的临床有效性。虽然许多研究试图总结具有抗菌活性的纳米颗粒,但从未进行过具有严格选择标准的全面审查。在这项工作中,系统回顾了 2012 年至 2019 年的文献,通过关注植物源性化合物的生长抑制活性,重点关注具有抗菌活性的植物源性化合物。本次综述共纳入459种化合物,其中酚类衍生物占50.8%,萜类化合物占26.6%,生物碱占5.7%,其他代谢物占17%。进一步讨论了 183 种化合物的抗菌活性、生物合成、构效关系、作用机制以及作为抗生素的潜力。还讨论了植物抗菌药物发现领域的新趋势。本综述提出了植物纳米粒子抗菌潜力的重要发现,供未来抗生素发现和开发工作考虑。
更新日期:2020-11-09
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