One of the most famous techniques for stomach ulcer imaging is the nuclear imaging technique. We aim to focus on the synthesis of ¹²⁵I-cimetidine (¹²⁵I-cim) as an agent for peptic ulcer imaging. Cimetidine was labeled with Iodine-125 using a different oxidizing agent (Ch-T, NBS). All factors affecting the labeling yield were optimized. The radiochemical yield of ¹²⁵I-cim was 98 ± 0.22% at optimum conditions. In vitro stability, in vivo biodistribution of ¹²⁵I-cimetidine was studied in three groups: control group, pretreated group, and ulcer bearing group. In vivo biodistribution studies of ¹²⁵I-cim revealed high uptake in the stomach ulcer, reaching about 75.4 ± 1.2% ID/g at 15 min post-injection, than pretreated groups compared to the control. The results showed the suitability of using ¹²⁵I-cimetidine for stomach ulcer imaging.

中文翻译：

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西咪替丁作为一种新型高选择性放射性示踪剂，用于消化性溃疡疾病的放射性碘标记和生物学评估

胃溃疡成像最著名的技术之一是核成像技术。我们的目标是专注于¹²⁵ I-西咪替丁（¹²⁵ I-cim）的合成，作为消化性溃疡成像的药物。使用另一种氧化剂（Ch-T，NBS）将碘美替丁（Imetine-125）标记为西咪替丁。所有影响标记产量的因素均已优化。在最佳条件下，¹²⁵ I-cim的放射化学产率为98±0.22％。在体外稳定性方面，研究了三组¹²⁵ I-西咪替丁的体内生物分布：对照组，预处理组和溃疡形成组。¹²⁵体内生物分布研究与对照组相比，I-cim显示胃溃疡的摄取量高，在注射后15分钟时达到约75.4±1.2％ID / g。结果显示使用¹²⁵ I-西咪替丁进行胃溃疡成像的适用性。