ABSTRACT

Hepatocellular carcinoma (HCC) is the most common primary liver cancer. Sirtuins are NAD+-dependent histone deacetylases that regulate many cellular processes such as proliferation, apoptosis, and metabolism. SIRT (silent information regulator)-1, 5, 6 and 7, members of the mammalian Sirtuin family of proteins (SIRT1–SIRT7), are involved in carcinogenesis, prognosis, metastasis, and chemical resistant of HCC. These proteins act through the deacetylation of tumor suppressor or oncogenic factors. MicroRNAs (miRNAs) are a group of small non-coding RNAs that down regulate gene expression by targeting the 3'-untranslated region of miRNAs. MiRNAs can function as tumor suppressors or as oncogenes and are involved in progression, differentiation, apoptosis and drug resistance of tumor cells. The focus of this review is to delineate the relationship between some microRNAs and their target, Sirtuins, and to present an overview of their function in HCC as currently understood.

摘要

肝细胞癌（HCC）是最常见的原发性肝癌。Sirtuins 是 NAD+ 依赖性组蛋白脱乙酰酶，可调节许多细胞过程，如增殖、凋亡和代谢。SIRT（沉默信息调节器）-1、5、6 和 7 是哺乳动物 Sirtuin 蛋白家族 (SIRT1–SIRT7) 的成员，参与 HCC 的致癌作用、预后、转移和化学抗性。这些蛋白质通过肿瘤抑制因子或致癌因子的脱乙酰作用起作用。MicroRNA (miRNA) 是一组小的非编码 RNA，它们通过靶向 miRNA 的 3'-非翻译区来下调基因表达。MiRNA可以作为抑癌基因或癌基因发挥作用，参与肿瘤细胞的进展、分化、凋亡和耐药性。