ABSTRACT

A film dressing is an easy and common wound management, which is flexible to cover many types of superficial injuries. In a recent study, we developed a scaffold from poly (1,8-octanediolco-citrate) incorporated decellularized amnion membrane (DAM-POC). The DAM-POC scaffold was biocompatible and could enhance soft and hard tissue regeneration when applied to repair the cleft palate in rat. The efficacy of the DAM-POC scaffold in oral repair had led us to hypothesize that it could be employed extensively in the medical field as a wound dressing. This study aimed to investigate the feasibility and efficacy of the DAM-POC scaffold as a film dressing in accelerating wound healing when applied in multiple tissue injuries. Our results demonstrated that both the DAM and DAM-POC scaffolds were biocompatible and anti-adhesive without causing severe foreign body reactions when covering wounds in abdominal wall, back muscle, tibia bone, and liver. In addition, the DAM-POC scaffold was superior to the DAM scaffold in reducing inflammation, preventing fibrosis, and regenerating tissues. In conclusion, the DAM-POC scaffold might potentially be adopted as a film dressing in a wide range of therapeutic applications and healing situations to protect the damaged tissues from the external environment and prevent infections.

摘要

薄膜敷料是一种简单且常见的伤口处理方法，可以灵活地覆盖多种类型的浅表损伤。在最近的一项研究中，我们开发了一种由聚（1,8-辛二醇柠檬酸酯）掺入脱细胞羊膜（DAM-POC）制成的支架。DAM-POC支架具有生物相容性，应用于修复大鼠腭裂时可以增强软组织和硬组织的再生。DAM-POC 支架在口腔修复中的功效使我们推测它可以作为伤口敷料广泛应用于医学领域。本研究旨在探讨 DAM-POC 支架作为薄膜敷料应用于多种组织损伤时加速伤口愈合的可行性和功效。我们的结果表明，DAM 和 DAM-POC 支架均具有生物相容性和抗粘连性，在覆盖腹壁、背部肌肉、胫骨和肝脏伤口时不会引起严重的异物反应。此外，DAM-POC支架在减轻炎症、防止纤维化和组织再生方面优于DAM支架。总之，DAM-POC 支架有可能在广泛的治疗应用和愈合情况中用作薄膜敷料，以保护受损组织免受外部环境的影响并防止感染。