ABSTRACT

Several authors have mentioned calculations of the effective atomic numbers ($Z_{eff}$) and effective electron density ($N_{eff}$) on amino acids, carbohydrates, and nucleotides. Recently, numerous studies performed for determination of the mass attenuation coefficient ($\mu /\rho$), $Z_{eff}$ and $N_{eff}$ on some biological compounds. However, theoretical studies for $Z_{eff}$, $N_{eff}$, and $\mu /\rho$ for any of chemotrapy drugs is not available in the literature. For 11 different chemoterapy drugs, which are cisplatin, carboplatin, oxaliplatin, ifosfamide, gemcitabine, fluorouracil, pemetrexed, etoposide, vincristine, tamoxifen ,and paclitaxel, by applying XCOM program we calculated the $\mu /\rho$ values, and from these values, the $Z_{eff}$and $N_{eff}$values have been acquired.$Z_{eff}$ $N_{eff}$ $Z_{eff}$ The minimum $Z_{eff}$ and $N_{eff}$ values were seen at approximately 0.1 MeV < E < 3 MeV energies where Compton scattering is dominant. When molecules are compared, we can see that $Z_{eff}$ reaches the highest values for cisplatin, carboplatin and oxaliplatin that contain Pt element and a minimum $Z_{eff}$ value is obtained for Vincristine. Because the $N_{eff}$ is related to $Z_{eff}$, the curves of the $N_{eff}$values on graphic exhibit same properties with $Z_{eff}$values. It is thought that $Z_{eff}$and $N_{eff}$ values presented in this study should be known for use in various medical applications such as radiology, radiation oncology, etc.

摘要

一些作者提到了有效原子序数的计算（${ž}_{ËFF}$）和有效电子密度（${ñ}_{ËFF}$），氨基酸，碳水化合物和核苷酸。最近，进行了许多研究以确定质量衰减系数（$\mu /\rho$）， ${ž}_{ËFF}$ 和 ${ñ}_{ËFF}$在一些生物化合物上。但是，针对${ž}_{ËFF}$， ${ñ}_{ËFF}$， 和 $\mu /\rho$文献中尚无用于任何化学趋化药物的药物。通过应用XCOM程序，对于11种不同的趋化性药物，包括顺铂，卡铂，奥沙利铂，异环磷酰胺，吉西他滨，氟尿嘧啶，培美曲塞，依托泊苷，长春新碱，他莫昔芬和紫杉醇，我们计算了$\mu /\rho$ 值，并从这些值中 ${ž}_{ËFF}$和 ${ñ}_{ËFF}$值已获取。${ž}_{ËFF}$ ${ñ}_{ËFF}$ ${ž}_{ËFF}$ 最小值 ${ž}_{ËFF}$ 和 ${ñ}_{ËFF}$大约在0.1 MeV <E <3 MeV能量处观察到该值，其中康普顿散射占主导。比较分子时，我们可以看到${ž}_{ËFF}$ 达到含有Pt元素的顺铂，卡铂和奥沙利铂的最大值，而最小值 ${ž}_{ËFF}$获得长春新碱的值。因为${ñ}_{ËFF}$ 与有关 ${ž}_{ËFF}$，曲线 ${ñ}_{ËFF}$图形上的值与 ${ž}_{ËFF}$价值观。被认为${ž}_{ËFF}$和 ${ñ}_{ËFF}$ 这项研究中提出的数值应众所周知，可用于各种医学应用，例如放射学，放射肿瘤学等。