The calcium channel TRPV6 is a novel regulator of RANKL‐induced osteoclastic differentiation and bone absorption activity through the IGF–PI3K–AKT pathway,Cell Proliferation

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The calcium channel TRPV6 is a novel regulator of RANKL‐induced osteoclastic differentiation and bone absorption activity through the IGF–PI3K–AKT pathway
Cell Proliferation ( IF 5.9 ) Pub Date : 2020-11-07 , DOI: 10.1111/cpr.12955
Jun Ma _{1,

2} , Lei Zhu ₁ , Zhibin Zhou ₃ , Tengfei Song ₁ , Lei Yang ₄ , Xu Yan ₅ , Aimin chen ₁ , Tian Wen Ye ₁

Affiliation

Calcium ion signals are important for osteoclast differentiation. Transient receptor potential vanilloid 6 (TRPV6) is a regulator of bone homeostasis. However, it was unclear whether TRPV6 was involved in osteoclast formation. Therefore, the aim of this study was to evaluate the role of TPRV6 in bone metabolism and to clarify its regulatory role in osteoclasts at the cellular level.

中文翻译：

钙通道 TRPV6 是通过 IGF-PI3K-AKT 通路调节 RANKL 诱导的破骨细胞分化和骨吸收活性的新型调节剂

钙离子信号对破骨细胞分化很重要。瞬时受体电位香草素 6 (TRPV6) 是骨稳态的调节剂。然而，尚不清楚 TRPV6 是否参与破骨细胞的形成。因此，本研究的目的是评估 TPRV6 在骨代谢中的作用，并在细胞水平上阐明其在破骨细胞中的调节作用。

更新日期：2020-11-07

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