Efficient Synthesis of Bulky 2,2’‐Bipyridine and (S)‐Pyridine‐Oxazoline Ligands,Advanced Synthesis & Catalysis

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Efficient Synthesis of Bulky 2,2’‐Bipyridine and (S)‐Pyridine‐Oxazoline Ligands
Advanced Synthesis & Catalysis ( IF 4.4 ) Pub Date : 2020-11-08 , DOI: 10.1002/adsc.202001218
Zhipeng Zheng ₁ , Patrick J. Walsh ₁

Affiliation

Bulky N,N’‐bidentate ligands can furnish catalysts with enhanced catalytic activity compared to commercially available ligands. Straightforward methods to effectively synthesize a broad range of these ligands, however, are uncommon. In this work, a simple and efficient method is developed for the synthesis of bulky N,N’‐bidentate ligands, including 2,2’‐bipyridines and enantioenriched pyridine‐oxazolines. The Pd/NIXANTPHOS catalyst system enabled synthesis of a series of bulky 2,2’‐bipyridine‐based ligands and (S)‐pyridine oxazoline‐based enantioenriched ligands with good to excellent yields. The ligands have been benchmarked in the aminofluorination of styrene.

中文翻译：

高效合成大体积的2,2'-联吡啶和（S）-吡啶-恶唑啉配体

与市售的配体相比，大体积的N，N '双齿配体可以提供具有增强的催化活性的催化剂。然而，直接合成有效范围广泛的这些配体的简单方法并不常见。在这项工作中，开发了一种简单有效的方法来合成庞大的N，N'-双齿配体，包括2,2'-联吡啶和对映体富集的吡啶-恶唑啉。Pd / NIXANTPHOS催化剂体系能够合成一系列庞大的2,2'-联吡啶基配体和（S）-吡啶恶唑啉基对映体富集的配体，收率良好或极好。配体已经在苯乙烯的氨基氟化中作了基准。

更新日期：2020-11-08

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