A Quantitative Description for Designing the Extrudability of Shear‐Thinning Physical Hydrogels,Macromolecular Bioscience

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A Quantitative Description for Designing the Extrudability of Shear‐Thinning Physical Hydrogels
Macromolecular Bioscience ( IF 4.4 ) Pub Date : 2020-11-08 , DOI: 10.1002/mabi.202000295
Hector Lopez Hernandez ₁ , Jason W Souza ₁ , Eric A Appel _{2,

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Affiliation

Physically associated hydrogels (PHs) capable of reversible transitions between solid and liquid‐like states have enabled novel strategies for 3D printing, therapeutic drug and cell delivery, and regenerative medicine. Among the many design criteria (e.g., viscoelasticity, cargo diffusivity, biocompatibility) for these applications, engineering PHs for extrudability is a necessary and critical design criterion for the successful application of these materials. As the development of many distinct PH material systems continues, a strategy to determine the extrudability of PHs a priori will be exceedingly useful for reducing costly and time‐consuming trial‐and‐error experimentation. Here, a strategy to determine the property–function relationships for PHs in injectable drug delivery applications at clinically relevant flow rates is presented. This strategy—validated with two chemically and physically distinct PHs—reveals material design spaces in the form of Ashby‐style plots that highlight acceptable, application‐specific material properties. It is shown that the flow behavior of PHs does not obey a single shear‐thinning power law and the implications for injectable drug delivery are discussed. This approach for generating design criteria has potential for streamlining the screening of PHs and their utility in applications with varying geometrical (i.e., needle diameter) and process (i.e., flow rate) constraints.

中文翻译：

设计剪切稀化物理水凝胶可挤出性的定量描述

物理相关水凝胶（PHs）能够在固态和液态之间可逆转变，为 3D 打印、治疗药物和细胞递送以及再生医学提供了新的策略。在这些应用的众多设计标准（例如，粘弹性、货物扩散性、生物相容性）中，可挤出性的工程 PH 是这些材料成功应用的必要和关键设计标准。随着许多不同 PH 材料系统的继续发展，先验确定 PH 的可挤出性的策略对于减少昂贵且耗时的试错实验将非常有用。在这里，提出了一种在临床相关流速下确定可注射给药应用中 PH 的特性 - 功能关系的策略。这种策略——通过两种化学和物理上不同的 PH 值进行验证——以阿什比风格的图的形式揭示了材料设计空间，突出了可接受的、特定于应用的材料特性。结果表明，PHs 的流动行为不服从单一的剪切稀化幂律，并讨论了对注射给药的影响。这种生成设计标准的方法有可能简化 PH 的筛选及其在具有不同几何（即针直径）和工艺（即流速）限制的应用中的效用。结果表明，PHs 的流动行为不服从单一的剪切稀化幂律，并讨论了对注射给药的影响。这种生成设计标准的方法有可能简化 PH 的筛选及其在具有不同几何（即针直径）和工艺（即流速）限制的应用中的效用。结果表明，PHs 的流动行为不服从单一的剪切稀化幂律，并讨论了对注射给药的影响。这种生成设计标准的方法有可能简化 PH 的筛选及其在具有不同几何（即针直径）和工艺（即流速）限制的应用中的效用。

更新日期：2020-11-08

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