BACKGROUND Water-soluble cellulose acetate (WSCA), a synthetic fiber source, was applied to human stool cultures and to pure cultures of representative Bacteroides species to characterize the fermentation properties of WSCA in the human gut, and to assess the potential availability of WSCA as a food or additive candidate. RESULTS All 9 of the different types of WSCA tested here provided increased acetate levels in human stool cultures. Greater levels of deacetylation were observed as the degree of substitution of hydroxyl groups by acetyl groups decreased. Among the 9 tested types of WSCA, CA-0.78-128 caused the largest shifts of the microbial community, including increased abundances of members of the genus Bacteroides, especially Bacteroides uniformis. Of 4 representative human gut Bacteroides species, only B. uniformis grew in pure culture on WSCA to actively produce acetate. CONCLUSION WSCA has potential for dietary application in human and other monogastric animals, based on the enhanced production of short-chain fatty acids (SCFAs), in particular acetate, in the hindgut. SCFA production is caused by selective proliferation of specific gut bacteria belonging to the genus Bacteroides. This article is protected by copyright. All rights reserved.

中文翻译：

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人类粪便培养物中水溶性醋酸纤维素发酵的化学和微生物表征

背景水溶性醋酸纤维素 (WSCA)，一种合成纤维来源，被应用于人类粪便培养物和代表性拟杆菌属物种的纯培养物，以表征 WSCA 在人类肠道中的发酵特性，并评估 WSCA 作为食品或添加剂候选者。结果 这里测试的所有 9 种不同类型的 WSCA 都提供了人类粪便培养物中增加的醋酸盐水平。随着乙酰基取代羟基的程度降低，观察到更高水平的脱乙酰化。在 9 种测试类型的 WSCA 中，CA-0.78-128 引起了微生物群落的最大变化，包括拟杆菌属成员的丰度增加，尤其是均匀拟杆菌。在 4 种代表性的人类肠道拟杆菌中，只有 B. 在 WSCA 上，uniformis 在纯培养物中生长以积极产生醋酸盐。结论 WSCA 具有在人类和其他单胃动物的饮食中应用的潜力，这是基于后肠中短链脂肪酸 (SCFA)，特别是醋酸盐的增加生产。SCFA 的产生是由属于拟杆菌属的特定肠道细菌的选择性增殖引起的。本文受版权保护。版权所有。