This work was designed to estimate the protective effect of Saraca indica L. leaves ethanolic exract against γ-irradiation induced renal damage in rats. Phytochemical examinations of S. indica L. leaves extract resulted in the separation of three flavanone glycosides: Astilibin (1), Neoastilbin (2), and Eriodictyol-7-O-α-l-rhamnopyranoside (3); two flavonols: Quercetin (4) and Quercetin-3-O-α-l-arabinopyranosyl-(1'''-6'')-O-β-D-galactopyranoside (5) in addition of Gallic acid (6) and methyl gallate (7). Their structures elucidated by chemical evidences and spectroscopic analysis (1 and 2D-NMR, -ESI-MS, UV). Female rats were used and classified into: control, Ext (200 mg/kg body wt/day orally for 7 days), IRR (8Gy), Ext + IRR, and Sily+IRR groups (received silymarin 50 mg/kg b.wt orally as reference drug). Results showed that S. indica L. leaves extract ameliorated the kidney function tests, hs-CRP, IL-1β, ACE, TNF-α, GSH, and MDA as well as, decreased the histopathological changes of kidney. In conclusion, S. indica L. leaves extract had a renoprotective activity against irradiation induced renal injury due to its flavononid contents.

中文翻译：

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Saraca indica L. 叶提取物（豆科植物）对雌性白化大鼠肾脏伽马辐射损伤的保护作用

这项工作旨在评估 Saraca indica L. 叶乙醇提取物对 γ 辐射诱导的大鼠肾损伤的保护作用。S. indica L. 叶提取物的植物化学检查导致分离出三种黄烷酮糖苷：落新地宾 (1)、新落新地宾 (2) 和 Eriodictyol-7-O-α-l-鼠李糖苷 (3)；两种黄酮醇：槲皮素 (4) 和槲皮素-3-O-α-l-阿拉伯吡喃糖基-(1'''-6'')-O-β-D-吡喃半乳糖苷 (5) 以及没食子酸 (6) 和没食子酸甲酯 (7)。通过化学证据和光谱分析（1 和 2D-​​NMR、-ESI-MS、UV）阐明了它们的结构。使用雌性大鼠并分为：对照、Ext（200 毫克/千克体重/天，口服 7 天）、IRR（8Gy）、Ext + IRR 和 Sily+IRR 组（接受 50 mg/kg b.wt 水飞蓟素）口服作为参考药物）。结果表明，S。籼稻叶提取物改善了肾功能测试，hs-CRP、IL-1β、ACE、TNF-α、GSH和MDA，并减少了肾脏的组织病理学变化。总之，由于其黄酮类化合物的含量，籼稻叶提取物对辐射诱导的肾损伤具有肾脏保护活性。