Voltammetric Study of the Antihistamine Drug Bilastine: Anodic Characterization and Quantification Using a Reusable MWCNTs Modified Screen Printed Carbon Electrode,Electroanalysis

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Voltammetric Study of the Antihistamine Drug Bilastine: Anodic Characterization and Quantification Using a Reusable MWCNTs Modified Screen Printed Carbon Electrode
Electroanalysis ( IF 2.7 ) Pub Date : 2020-11-08 , DOI: 10.1002/elan.202060494
Jorge Ginja Teixeira _{1,

2} , João Oliveira ₁

Affiliation

The anodic behaviour and the electroanalytical quantification of the second‐generation antihistamine bilastine (BIL) were investigated for the first time. A multi‐walled carbon nanotubes (MWCNTs) film‐coated screen printed carbon electrode (SPCE), as well as cyclic (CV) and linear sweep (LSV) voltammetry, were used for that purpose. The results showed that BIL undergoes an irreversible two‐electron oxidation process at the MWCNTs‐SPCE sensor. It was also found that the sensor can be reused after a simple and rapid reconditioning procedure. The proposed method was applied to the quantification of BIL in pharmaceutical formulations and spiked urine samples, and good recoveries were obtained.

中文翻译：

抗组胺药Bilastine伏安法研究：阳极表征和定量使用可重复使用的MWCNTs修饰的丝网印刷碳电极

首次研究了第二代抗组胺双弹性蛋白（BIL）的阳极行为和电分析定量。为此，使用了多壁碳纳米管（MWCNTs）膜涂覆的丝网印刷碳电极（SPCE）以及循环（CV）和线性扫描（LSV）伏安法。结果表明，BIL在MWCNTs-SPCE传感器上经历了不可逆的两电子氧化过程。还发现，在简单，快速的修复程序之后，传感器可以重复使用。将该方法用于药物制剂和加标尿液样品中BIL的定量分析，回收率良好。

更新日期：2020-11-08

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