Puzzling Out the Colchicine Biosynthetic Pathway,ChemMedChem

当前位置： X-MOL 学术 › ChemMedChem › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Puzzling Out the Colchicine Biosynthetic Pathway
ChemMedChem ( IF 3.6 ) Pub Date : 2020-11-09 , DOI: 10.1002/cmdc.202000633
Emily A Stander ₁ , Nicolas Papon _{2,

3} , Vincent Courdavault ₁

Affiliation

Colchicine is among the oldest plant natural products (NPs) still used for treating a broad spectrum of human diseases including gout and other articular inflammation disorders. This molecule is synthesized by several herbaceous species related to the Liliaceae family, but in very low quantities in whole plants. As for many pharmaceutical compounds from plants, the production of colchicine still depends on the natural resource from which it is extracted. From the past decade, metabolic engineering has progressively become a credible alternative for the cost‐effective large‐scale production of several valuable NPs. In the same vein, Nett and colleagues recently reported an unprecedented advance in the field for colchicine. By using a combination of transcriptomics, metabolomics and pathway reconstitution, Sattely's group deciphered a near‐complete biosynthetic pathway to colchicine without prior knowledge of biosynthetic genes. Besides constituting a benchmark for the elucidation of natural product biosynthetic pathways, it opens unprecedented perspectives regarding metabolic engineering of colchicine biosynthesis.

中文翻译：

秋水仙碱生物合成途径之谜

秋水仙碱是最古老的植物天然产物 (NPs) 之一，至今仍用于治疗包括痛风和其他关节炎症在内的多种人类疾病。该分子由与百合科相关的几种草本物种合成，但在整个植物中的含量非常低。至于来自植物的许多药物化合物，秋水仙碱的生产仍然取决于提取它的自然资源。在过去的十年中，代谢工程逐渐成为几种有价值的 NP 的具有成本效益的大规模生产的可靠替代方案。同样，Nett 及其同事最近报告了秋水仙碱领域前所未有的进展。通过使用转录组学、代谢组学和通路重建的组合，Sattely' s 小组在没有生物合成基因的先验知识的情况下破译了一条接近完整的秋水仙碱生物合成途径。除了构成阐明天然产物生物合成途径的基准外，它还为秋水仙碱生物合成的代谢工程开辟了前所未有的前景。

更新日期：2020-11-09

点击分享查看原文

点击收藏

阅读更多本刊最新论文本刊介绍/投稿指南11