Recent Advances in Metal‐catalyzed Alkylation, Alkenylation and Alkynylation of Indole/indoline Benzenoid Nucleus,Chemistry - An Asian Journal

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Recent Advances in Metal‐catalyzed Alkylation, Alkenylation and Alkynylation of Indole/indoline Benzenoid Nucleus
Chemistry - An Asian Journal ( IF 3.5 ) Pub Date : 2020-11-08 , DOI: 10.1002/asia.202001159
Sourav Pradhan ₁ , Pinaki Bhusan De ₁ , Tariq A. Shah _{1,

2} , Tharmalingam Punniyamurthy ₁

Affiliation

Selective editing of the benzenoid C−H bonds (C4−C7) in indoles/indolines has received great interest because functionalized indoles/indolines are featured in many marketed drugs and natural products. Transition‐metal‐catalyzed directed C−H functionalization has thus been developed to manipulate the benzenoid core through C−C and C‐heteroatom bond formation. This review covers the recent advances in selective C−C bond forming reactions, alkylation, alkenylation and alkynylation, over the benzenoid ring (C4−C7) of indoles/indolines using metal catalysis.

中文翻译：

金属催化的吲哚/吲哚类苯系物核的烷基化，烯基化和炔化的最新进展

由于在许多市售药物和天然产品中都存在功能化的吲哚/二氢吲哚，选择性编辑吲哚/二氢吲哚中的苯甲酰CH键（C4-C7）引起了极大的兴趣。因此，已经开发出过渡金属催化的定向C H功能化，以通过C C和C杂原子键的形成来操纵类苯环。这篇综述涵盖了使用金属催化在吲哚/二氢吲哚的苯环（C4-C7）上选择性CC键形成反应，烷基化，烯基化和炔基化的最新进展。

更新日期：2020-12-16

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