<br>无氟二维碳化铌 MXene 作为超高灵敏度电化学生物传感器的稳定且生物相容的纳米平台,Advanced Science

当前位置： X-MOL 学术 › Adv. Sci. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

无氟二维碳化铌 MXene 作为超高灵敏度电化学生物传感器的稳定且生物相容的纳米平台
Advanced Science ( IF 14.3 ) Pub Date : 2020-11-09 , DOI: 10.1002/advs.202001546
Menglin Song ₁ , Sin-Yi Pang ₁ , Feng Guo ₁ , Man-Chung Wong ₁ , Jianhua Hao ₁

Affiliation

近年来，二维碳化铌MXene由于其大表面积、良好的金属导电性和可调谐带隙的优点而受到广泛关注，使其具有多种应用前景。然而，传统合成路线中使用剧毒的含氟蚀刻剂和较长的蚀刻时间极大地阻碍了MXene的进一步探索，尤其限制了其在生物医学领域的应用。在此，通过电化学蚀刻（E蚀刻）剥离的简便策略制备了新型无氟Nb ₂ CT _x纳米片。利用电刻蚀 MXene 的快速铝清除率、优异的化学稳定性和生物相容性，构建了基于无氟 Nb ₂ CT _x /乙酰胆碱酯酶的生物传感器，用于亚胺磷检测，检测限低至 0.046 ng mL ^-1 。所制造的基于 Nb ₂ CT _x的生物传感器优于氢氟酸蚀刻 Nb ₂ CT _x的对应物，这表明无氟 MXene 可以增强生物传感器中的酶活性和电子转移。结果证明，无氟 MXene 有利于开发具有超高灵敏度和选择性的高性能生物传感器。人们高度期待无氟 MXene 作为一种稳定且生物相容的纳米平台，具有扩展到许多其他生物医学领域的巨大潜力。

"点击查看英文标题和摘要"

Fluoride‐Free 2D Niobium Carbide MXenes as Stable and Biocompatible Nanoplatforms for Electrochemical Biosensors with Ultrahigh Sensitivity

Recently, 2D niobium carbide MXene has drawn vast attention due to its merits of large surface area, good metallic conductivity, and tunable band gap, making it desirable for various applications. However, the usage of highly toxic fluoride‐containing etchant and quite long etching time in the conventional synthesis route has greatly hindered further exploration of MXene, especially restricting its biomedical application. Herein, novel fluoride‐free Nb₂CT_x nanosheets are prepared by a facile strategy of electrochemical etching (E‐etching) exfoliation. Taking advantage of rapid aluminum clearance, excellent chemical stability, and biocompatibility from the MXene by E‐etching, fluoride‐free Nb₂CT_x/acetylcholinesterase‐based biosensors are constructed for phosmet detection with the limit of detection down to 0.046 ng mL⁻¹. The fabricated Nb₂CT_x‐based biosensor is superior to the counterpart from hydrofluoric acid‐etched Nb₂CT_x, indicating that fluoride‐free MXene can enhance the enzyme activity and electron transfer in the biosensor. The results prove that the fluorine‐free MXene shows promise for developing biosensors with high performance of ultrahigh sensitivity and selectivity. It is highly expected that the fluoride‐free MXene as a stable and biocompatible nanoplatform has great potential to be expanded to many other biomedical fields.

更新日期：2020-12-16

点击分享查看原文

点击收藏

公开下载

阅读更多本刊最新论文本刊介绍/投稿指南11