上转换纳米颗粒的可控组装增强了肿瘤细胞的穿透力和杀伤效率,Advanced Science

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上转换纳米颗粒的可控组装增强了肿瘤细胞的穿透力和杀伤效率
Advanced Science ( IF 15.1 ) Pub Date : 2020-11-07 , DOI: 10.1002/advs.202001831
Zhen Zhang ₁ , Juwita Norasmara Rahmat ₁ , Ratha Mahendran ₂ , Yong Zhang _{1,

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Affiliation

上转换纳米粒子（UCNPs）用于治疗深层癌症和大肿瘤的方法最近获得了发展。先前已经描述了使用非共价物理吸附和共价结合将光敏剂（PS）加载到UCNP的常规方法。但是，这些方法很耗时，并且需要额外的修改步骤。很少有人报道在受控的UCNPs组装过程中引入PS负载。在这项研究中，两亲共聚物，聚（苯乙烯-共顺丁烯二酸酐），用于指示UCNP组装成各种大小受控的UCNP簇，单个UCNP之间形成的间隙区可用于封装PS。这种纳米结构的生产过程导致装载PS和其他化合物的方法相当简单和可靠。同样，在考虑了PS负载量，在3D膀胱肿瘤类器官中的渗透率和单线态氧产生等因素后，与单个和大型簇相比，小的UCNP簇显示出了优异的细胞杀伤力。因此，这些大小不同的UCNP簇可以促进对细胞杀伤的基于纳米颗粒的递送平台系统的清晰和深入的了解，并可能为基于UCNP的其他领域的应用铺平道路。

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Controllable Assembly of Upconversion Nanoparticles Enhanced Tumor Cell Penetration and Killing Efficiency

The use of upconversion nanoparticles (UCNPs) for treating deep‐seated cancers and large tumors has recently been gaining momentum. Conventional approaches for loading photosensitizers (PS) to UCNPs using noncovalent physical adsorption and covalent conjugation had been previously described. However, these methods are time‐consuming and require extra modification steps. Incorporating PS loading during the controlled UCNPs assembly process is seldom reported. In this study, an amphiphilic copolymer, poly(styrene‐co‐maleic anhydride), is used to instruct UCNPs assembly formations into well‐controlled UCNPs clusters of various sizes, and the gap zones formed between individual UCNPs can be used to encapsulate PS. This nanostructure production process results in a considerably simpler and reliable method to load PS and other compounds. Also, after considering factors such as PS loading quantity, penetration in 3D bladder tumor organoids, and singlet oxygen production, the small UCNPs clusters displayed superior cell killing efficacy compared to single and big sized clusters. Therefore, these UCNPs clusters with different sizes could facilitate a clear and deep understanding of nanoparticle‐based delivery platform systems for cell killing and may pave a new way for other fields of UCNPs based applications.

更新日期：2020-12-16

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