The protease SPRTN emerged as the essential enzyme for DNA–protein crosslink proteolysis repair. Biochemical and cell biological work indicated that SPRTN is a nonspecific protease. Recent and independent studies from Lou, Stingele, and Ramadan reveal that SPRTN activity is modulated via three layers of regulation that make it selective for DNA–protein crosslinks.

中文翻译：

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SPRTN 蛋白酶调控的三位一体

蛋白酶 SPRTN 成为 DNA-蛋白质交联蛋白水解修复的必需酶。生化和细胞生物学工作表明SPRTN是一种非特异性蛋白酶。 Lou、Stingele 和 Ramadan 最近的独立研究表明，SPRTN 活性通过三层调控进行调节，使其对 DNA-蛋白质交联具有选择性。