The study of regenerative dentistry receives a fast growing interest. The potential ability of the dentin-pulp complex to regenerate is both promising and perplexing. To answer the challenging nature of the dental environment, scientists have developed various combinations of biomaterial scaffolds, stem cells, and incorporation of several growth factors. One of the crucial elements of this tissue engineering plan is the selection and fabrication of scaffolds. However, further findings suggest that cell behavior hugely depends on mechanical signaling. Nanotopography modifies scaffolds to alter cell migration and differentiation. However, to the best of the author's knowledge, there are very few studies addressing the correlation between nanotopography and dentin-pulp complex regeneration. Therefore, this article presents a comprehensive review of these studies and suggests a direction for future developments, particularly in the incorporation of nanotopography design for dentin-pulp complex regeneration.

再生牙科的研究受到了快速增长的兴趣。牙本质-纸浆复合物再生的潜在能力是有前途的和令人困惑的。为了应对牙科环境的挑战性性质，科学家开发了生物材料支架，干细胞的多种组合，并结合了多种生长因子。该组织工程计划的关键要素之一是支架的选择和制造。然而，进一步的发现表明细胞行为在很大程度上取决于机械信号传导。纳米形貌修饰支架以改变细胞迁移和分化。然而，据作者所知，很少有研究涉及纳米形貌与牙本质浆复合体再生之间的相关性。因此，